Saeedian Kasra, Davaryar Saeed, Emadzadeh Maryam, Rezayat Alireza Akhavan
Department of Radiology, Babol University of Medical Sciences, Babol, Iran.
Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Trials. 2025 Jan 31;26(1):36. doi: 10.1186/s13063-025-08740-x.
To evaluate the impact of vitamin E supplementation on sperm analysis results in patients post-varicocelectomy.
This single-center, triple-blind, randomized controlled trial was conducted at Imam Reza Hospital, Mashhad, Iran. Ninety male patients, aged 15-25 years, with infertility and varicocele grade 2 or 3, were randomized into two groups. The intervention group received 400 units of vitamin E daily for 3 months, while the control group received a placebo. Sperm analysis was conducted before and 3 months after the intervention. Statistical analyses were performed using SPSS version 23, with significance set at P < 0.05.
A total of 90 patients were enrolled and equally randomized into two groups (n = 45 per group). The mean age was 30.68 ± 6.31 years. Post-intervention, the improvement in sperm motility was significantly higher in the vitamin E group compared to the placebo group (P = 0.03). Both groups showed significant improvements in sperm motility, count, and morphology from pre- to post-intervention (P < 0.001).
Vitamin E supplementation post-varicocelectomy is associated with improved sperm parameters, suggesting potential benefits in the management of male infertility related to varicocele. However, varicocelectomy alone also results in significant improvements.
This study is registered at the Iranian Registry of Clinical Trials (IRCT20200911048689N1). Registered on October 10, 2020.
评估补充维生素E对精索静脉曲张切除术后患者精液分析结果的影响。
本单中心、三盲、随机对照试验在伊朗马什哈德伊玛目礼萨医院进行。90例年龄在15 - 25岁、患有不育症且精索静脉曲张为2级或3级的男性患者被随机分为两组。干预组每天服用400单位维生素E，持续3个月，而对照组服用安慰剂。在干预前和干预后3个月进行精液分析。使用SPSS 23版进行统计分析，显著性设定为P < 0.05。
共纳入90例患者，平均分为两组（每组n = 45）。平均年龄为30.68 ± 6.31岁。干预后，维生素E组精子活力的改善显著高于安慰剂组（P = 0.03）。两组从干预前到干预后精子活力、数量和形态均有显著改善（P < 0.001）。
精索静脉曲张切除术后补充维生素E与精液参数改善有关，提示在治疗与精索静脉曲张相关的男性不育症方面可能有益。然而，单纯精索静脉曲张切除术也会带来显著改善。
本研究已在伊朗临床试验注册中心注册（IRCT20200911048689N1）。于2020年10月10日注册。
