Ener K, Aldemir M, Işık E, Okulu E, Özcan M F, Uğurlu M, Tangal S, Özayar A
Department of Urology, Ankara Ataturk Training and Research Hospital, Ankara, Turkey.
Department of Biostatistics, School of Medicine, Ankara Ataturk Training and Research Hospital, Yildirim Beyazit University, Ankara, Turkey.
Andrologia. 2016 Sep;48(7):829-34. doi: 10.1111/and.12521. Epub 2016 Jan 19.
In this study, we aimed to investigate the impact of vitamin E supplementation on semen parameters and pregnancy after varicocelectomy. Forty-five infertile male patients who were diagnosed with varicocele and underwent subinguinal varicocelectomy were included in the study. After performing subinguinal varicocelectomy, the patients were randomised into two groups: 22 receiving vitamin E for 12 months, and 23 as the control group without receiving any supplementation. The pre-operative parameters of semen analyses and pregnancy rates of both groups were compared with those of post-operative parameters. There were no statistically significant differences between the groups in terms of sperm count and motile sperm percentage, in pre-operative, post-operative 3rd month, post-operative 6th month and post-operative 12th month periods. Repeated-measures anova was performed, and sperm count, percentage of change in sperm count, motile sperm count and percentage of change in motile sperm count of the groups were compared. The administration of vitamin E increased all of these parameters; however, they were not found to be statistically significant. In conclusion, vitamin E supplementation might improve the sperm parameters after varicocelectomy; however, further studies including larger number of samples are needed to make a proper decision on vitamin E supplementation after varicocelectomy.
在本研究中，我们旨在探讨补充维生素E对精索静脉曲张切除术后精液参数及妊娠情况的影响。45例被诊断为精索静脉曲张并接受腹股沟下精索静脉曲张切除术的不育男性患者纳入本研究。在进行腹股沟下精索静脉曲张切除术后，患者被随机分为两组：22例接受维生素E治疗12个月，23例作为对照组不接受任何补充治疗。比较两组术前精液分析参数和妊娠率与术后参数。在术前、术后第3个月、术后第6个月和术后第12个月期间，两组在精子计数和活动精子百分比方面无统计学显著差异。进行重复测量方差分析，并比较两组的精子计数、精子计数变化百分比、活动精子计数和活动精子计数变化百分比。维生素E的给药增加了所有这些参数；然而，未发现它们具有统计学显著性。总之，补充维生素E可能会改善精索静脉曲张切除术后的精子参数；然而，需要包括更多样本的进一步研究，以便对精索静脉曲张切除术后补充维生素E做出恰当决策。
