Kafian-Attari Iman, Ebrahimi Mohammad, Nippolainen Ervin, Mirhashemi Arash, Paakkari Petri, Bergmann Florian, Foschum Florian, Kienle Alwin, Töyräs Juha, Afara Isaac
Department of Technical Physics, University of Eastern Finland, Kuopio, Finland.
Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland.
J Biophotonics. 2025 Apr;18(4):e202400460. doi: 10.1002/jbio.202400460. Epub 2025 Jan 31.
This study investigates the relationship between the optical properties of articular cartilage with its biomechanical parameters. The absorption and reduced scattering coefficients of articular cartilage, and average maximum penetration depth, average maximum lateral spread, and average path length of photons were estimated by optical measurements and Monte Carlo simulation. The equilibrium and instantaneous moduli, and initial fibrillar network, strain-dependent fibrillar network, and nonfibrillar network moduli, and initial and deformation-dependent permeability of the tissue were estimated by multistep stress-relaxation measurement and fibril-reinforced poroelastic modeling. The relationship between the optical properties and biomechanical parameters was assessed using predictive regression modeling. A strong relationship was found between reduced scattering coefficients, averaged maximum penetration depth, averaged maximum lateral spread, and average path length of photons with equilibrium, instantaneous, and initial fibrillar network moduli. We attribute this relationship to the collagen fibers as the main contributor to the scattering and biomechanical properties of the tissue.
本研究调查了关节软骨的光学特性与其生物力学参数之间的关系。通过光学测量和蒙特卡罗模拟估算了关节软骨的吸收系数和约化散射系数，以及光子的平均最大穿透深度、平均最大横向扩展和平均路径长度。通过多步应力松弛测量和纤维增强多孔弹性模型估算了组织的平衡模量和瞬时模量、初始纤维网络、应变相关纤维网络和非纤维网络模量，以及组织的初始渗透率和变形相关渗透率。使用预测回归模型评估了光学特性与生物力学参数之间的关系。发现光子的约化散射系数、平均最大穿透深度、平均最大横向扩展和平均路径长度与平衡模量、瞬时模量和初始纤维网络模量之间存在密切关系。我们将这种关系归因于胶原纤维，因为它是组织散射和生物力学特性的主要贡献者。
