Kumar Pradeep, Kumar Anil, Kumar Virendra
Department of NMR, All India Institute of Medical Sciences, New Delhi, India.
Gene Regulation Laboratory, National Institute of Immunology, New Delhi, India.
Cell Biochem Funct. 2025 Feb;43(2):e70050. doi: 10.1002/cbf.70050.
Prostate cancer (PCa) is the most commonly detected malignancy in men worldwide. PCa is a slow-growing cancer with the absence of symptoms at early stages. The pathogenesis has not been entirely understood including the key risk factors related to PCa development like diet and microbiota derived metabolites. Microbiota may influence the host's immunological responses, inflammatory responses, and metabolic pathways, which may be crucial for the development and metastasis. Similarly, short-chain fatty acids, methylamines, hippurate, bile acids, and other metabolites generated by microbiota may have potential roles in cancer inflammation and progression of cancer. Most studies have focused on the role of metabolites and their pathways involved in chronic inflammation, tumor initiation, proliferation, and progression. In summary, the review discusses the role of microbiota and microbial-derived metabolite-built strategies in inflammation and progression of the PCa.
前列腺癌（PCa）是全球男性中最常被检测出的恶性肿瘤。PCa是一种生长缓慢的癌症，早期没有症状。其发病机制尚未完全明确，包括与PCa发展相关的关键风险因素，如饮食和微生物群衍生的代谢产物。微生物群可能影响宿主的免疫反应、炎症反应和代谢途径，这对癌症的发展和转移可能至关重要。同样，微生物群产生的短链脂肪酸、甲胺、马尿酸盐、胆汁酸和其他代谢产物可能在癌症炎症和癌症进展中发挥潜在作用。大多数研究都集中在代谢产物及其参与慢性炎症、肿瘤起始、增殖和进展的途径的作用上。总之，本综述讨论了微生物群和微生物衍生代谢产物构建策略在PCa炎症和进展中的作用。
