Innovative applications of medium- and long-chain triacylglycerol in nutritional support: Current perspectives and future directions.

As a unique structured lipid, medium- and long-chain triacylglycerol (MLCT) is characterized by the combination of medium- and long-chain fatty acids in a single triacylglycerol molecule. In recent years, MLCT, as a nutritional lipid, has gradually emerged as a research hot topic in the fields of food science and nutrition. This paper innovatively provides a comprehensive review of the current application status and development prospects of MLCT in nutritional support. First, the basic principles defining characteristics and selection basis of both enteral and parenteral nutrition are analyzed, elucidating the differences between the two modalities in terms of nutrient delivery pathway, absorption mechanisms, and physiological effects. Subsequently, the natural sources and artificial synthetic pathways of MLCT along with its metabolic behavior in vivo are elaborated. On this basis, the latest research advancements in the application of MLCT in both nutritional models are reviewed, with a particular emphasis on current research hotspots. Finally, the challenges encountered in the practical application of MLCT are discussed, and the future trajectory of MLCT as a functional lipid is predicted. In particular, the innovative potential of MLCT in functional foods, food for special medical purposes, personalized nutrition, and other aspects is emphasized, which provides beneficial ideas and directions for further research and industrial applications of MLCT.