Zhang Yongtao, Zhou Chao, Xie Qiong, Xia Linying, Liu Lu, Bao Wenwen, Lin Hongming, Xiong Xiaochun, Zhang Hao, Zheng Zeping, Zhao Jiayi, Liang Wenqing
Department of Orthopedics, Zhoushan Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Zhoushan, China.
Department of Orthopedics, Zhoushan Guanghua Hospital, Zhoushan, Zhejiang, China.
Nanomedicine (Lond). 2025 Feb;20(4):371-388. doi: 10.1080/17435889.2025.2457317. Epub 2025 Jan 31.
Advancements in tissue regeneration, particularly bone regeneration is key area of research due to potential of novel therapeutic approaches. Efforts to reduce reliance on autologous and allogeneic bone grafts have led to the development of biomaterials that promote synchronized and controlled bone healing. However, the use of growth factors is limited by their short half-life, slow tissue penetration, large molecular size and potential toxicity. These factors suggest that traditional delivery methods may be inadequate hence, to address these challenges, new strategies are being explored. These novel approaches include the use of bioactive substances within advanced delivery systems that enable precise spatiotemporal control. Dual-release composite scaffolds offer a promising solution by reducing the need for multiple surgical interventions and simplifying the treatment process. These scaffolds allow for sustained and controlled drug release, enhancing bone repair while minimizing the drawbacks of conventional methods. This review explores various dual-drug release systems, discussing their modes of action, types of drugs used and release mechanisms to improve bone regeneration.
组织再生，尤其是骨再生方面的进展，由于新型治疗方法的潜力，是关键的研究领域。减少对自体和异体骨移植依赖的努力促使了促进同步和可控骨愈合的生物材料的发展。然而，生长因子的使用受到其半衰期短、组织穿透缓慢、分子量大和潜在毒性的限制。这些因素表明传统的递送方法可能不足，因此，为应对这些挑战，正在探索新的策略。这些新方法包括在先进的递送系统中使用生物活性物质，从而实现精确的时空控制。双释放复合支架通过减少多次手术干预的需求并简化治疗过程，提供了一个有前景的解决方案。这些支架能够实现持续和可控的药物释放，增强骨修复，同时将传统方法的缺点降至最低。本文综述探讨了各种双药释放系统，讨论了它们的作用方式、所用药物类型和释放机制，以改善骨再生。
