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黄蜂、胡蜂和小黄蜂毒液蛋白的抗原交叉反应性。

Antigenic cross-reactivity of venom proteins from hornets, wasps, and yellow jackets.

作者信息

King T P, Joslyn A, Kochoumian L

出版信息

J Allergy Clin Immunol. 1985 May;75(5):621-8. doi: 10.1016/0091-6749(85)90040-5.

DOI:10.1016/0091-6749(85)90040-5
PMID:3989148
Abstract

The venoms of hornets, wasps, and yellow jackets have similar protein compositions. The three major venom proteins are antigen 5, hyaluronidase, and phospholipase A1. These proteins, which are allergens in man, have been isolated and compared for their biochemical and antigenic properties. The homologous proteins from these vespids have very similar biochemical properties that include their molecular size and charge, their amino acid composition, and, where it is applicable, their enzymatic activities. They were studied for their antigenic cross-reactivity with specific mouse antibodies. The phospholipases demonstrated no detectable antigenic cross-reactivity, whereas the antigen 5s and hyaluronidases demonstrated varying extents of cross-reactivity.

摘要

黄蜂、胡蜂和小黄蜂的毒液具有相似的蛋白质组成。三种主要的毒液蛋白是抗原5、透明质酸酶和磷脂酶A1。这些在人体内属于过敏原的蛋白质已被分离出来,并对其生化和抗原特性进行了比较。这些胡蜂科昆虫的同源蛋白具有非常相似的生化特性,包括它们的分子大小和电荷、氨基酸组成,以及在适用情况下的酶活性。研究了它们与特定小鼠抗体的抗原交叉反应性。磷脂酶未显示出可检测到的抗原交叉反应性,而抗原5和透明质酸酶则显示出不同程度的交叉反应性。

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Antigenic cross-reactivity of venom proteins from hornets, wasps, and yellow jackets.黄蜂、胡蜂和小黄蜂毒液蛋白的抗原交叉反应性。
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