内皮型一氧化氮合酶（eNOS）rs2070744基因多态性与子痫前期关联的系统评价和荟萃分析
A systematic review and meta-analysis of the association between endothelial nitric oxide synthase (eNOS) rs2070744 polymorphism and preeclampsia.
作者信息
Hossen Md Shafiul, Aziz Md Abdul, Barek Md Abdul, Islam Mohammad Safiqul
机构信息
Department of Pharmacy, State University of Bangladesh, Kanchan, Rupganj, Narayanganj, Dhaka 1461, Bangladesh; Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh; Laboratory of Pharmacogenomics and Molecular Biology, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh.
Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh; Laboratory of Pharmacogenomics and Molecular Biology, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh; Bangladesh Pharmacogenomics Research Network (BdPGRN), Bangladesh.
出版信息
Cytokine. 2025 Mar;187:156870. doi: 10.1016/j.cyto.2025.156870. Epub 2025 Jan 31.
OBJECTIVE
Preeclampsia, characterized by hypertension and proteinuria, is a medical condition associated with maternal and fetal morbidity and mortality. Previous studies reported conflicting correlations between the eNOS rs2070744 variant and the occurrence of preeclampsia. Due to inconsistencies in findings, the purpose of the present meta-analysis was to explore the precise link between the eNOS rs2070744 variant and the development of preeclampsia.
METHODS
The articles were retrieved from various online sources, including Cochrane Library, Google Scholar, EMBASE, PubMed, and Web of Science databases up to February 2024. Data were analyzed by Review Manager (RevMan) 5.4. We adhered to the PRISMA 2020 guidelines to conduct this meta-analysis.
RESULTS
A total of 26 articles containing 3741 cases and 4920 controls were included for qualitative and quantitative data synthesis. In the overall population, we found a strong correlation between the eNOS rs2070744 variant and higher preeclampsia risk in recessive (CC vs. CT + TT: OR = 1.31, p = 0.017) dominant (CC + CT vs. TT: OR = 1.14, p = 0.051), co-dominant 2 (CC vs. TT: OR = 1.37, p = 0.011) and allelic (C vs. T: OR = 1.14, p = 0.022) models. Our study also explored similar outcomes among the Caucasian population in dominant (CC + CT vs. TT: OR = 1.16, p = 0.048), recessive (CC vs. CT + TT: OR = 1.46, p = 0.027), allele (C vs. T: OR = 1.18, p = 0.044), co-dominant 2 (CC vs. TT: OR = 1.53, p = 0.027), and co-dominant 3 (CC vs. CT: OR = 1.46, p = 0.002) models. Besides, a significant risk of preeclampsia in the African population was observed in co-dominant 2 (CC vs. TT: OR = 2.11, p = 0.009), dominant (CC + CT vs. TT: OR = 1.58, p = 0.002) and allelic (C vs. T: OR = 1.45, p = 0.001) models. However, no association of this polymorphism with preeclampsia risk was reported in Asian and mixed populations.
CONCLUSION
This study suggests a significant correlation between eNOS rs2070744 polymorphism and preeclampsia. However, more research on various ethnic groups is necessary to confirm the association.
目的
子痫前期以高血压和蛋白尿为特征，是一种与母婴发病率和死亡率相关的病症。先前的研究报道了内皮型一氧化氮合酶（eNOS）基因rs2070744变异与子痫前期发生之间相互矛盾的相关性。由于研究结果不一致，本荟萃分析的目的是探讨eNOS rs2070744变异与子痫前期发展之间的确切联系。
方法
从包括Cochrane图书馆、谷歌学术、EMBASE、PubMed和科学网数据库在内的各种在线资源中检索截至2024年2月的文章。使用Review Manager（RevMan）5.4进行数据分析。我们遵循PRISMA 2020指南进行这项荟萃分析。
结果
总共纳入了26篇文章，包含3741例病例和4920例对照，用于定性和定量数据综合分析。在总体人群中，我们发现eNOS rs2070744变异与子痫前期风险增加在隐性（CC与CT + TT相比：优势比[OR]=1.31，p = 0.017）、显性（CC + CT与TT相比：OR = 1.14，p = 0.051）、共显性2（CC与TT相比：OR = 1.37，p = 0.011）和等位基因（C与T相比：OR = 1.14，p = 0.022）模型中存在强相关性。我们的研究还在白种人群中探讨了类似结果，在显性（CC + CT与TT相比：OR = 1.16，p = 0.048）、隐性（CC与CT + TT相比：OR = 1.46，p = 0.027）、等位基因（C与T相比：OR = 1.18，p = 0.044）、共显性2（CC与TT相比：OR = 1.53，p = 0.027）和共显性3（CC与CT相比：OR = 1.46，p = 0.
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