Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh; Laboratory of Pharmacogenomics and Molecular Biology, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh.
Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh; Laboratory of Pharmacogenomics and Molecular Biology, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh; Bangladesh Pharmacogenomics Research Network (BdPGRN), Bangladesh.
Cytokine. 2024 Mar;175:156499. doi: 10.1016/j.cyto.2024.156499. Epub 2024 Jan 10.
Preeclampsia is a serious medical condition that significantly affects expectant mothers. Growing research showed an inconsistent association between TNF-alfa rs1800629 polymorphism and preeclampsia. The current meta-analysis was aimed at examining the potential impact of rs1800629 variant on preeclampsia.
The Cochrane Library, Google Scholar, PubMed, EMBASE, Web of Science, and other databases were searched extensively to locate and select articles up to October 30, 2023. The PRISMA 2020 recommendations were followed to perform this study. Data analysis was done by using Comprehensive Meta analysis (v 3).
We have included 32 articles containing 35 studies with 3,883 patients and 5,821 controls for qualitative and quantitative data analysis. We found a strong relationship between rs1800629 variant with the increased preeclampsia risk in co-dominant model 1 (OR = 1.33, p = 0.019), co-dominant model 2 (OR = 1.43, p = 0.014), dominant model (OR = 1.25, p = 0.044), over-dominant model (OR = 1.31, p = 0.021), and allelic model (OR = 1.24, p = 0.018). This study also revealed a significantly higher risk among the Asian population in the dominant (OR = 2.31, p = 0.036) and allelic model (OR = 2.02, p = 0.028). For the Caucasian population, an increased association between the rs1800629 variant and preeclampsia risk was reported in co-dominant model 1 (OR = 1.37, p = 0.011), co-dominant model 2 (OR = 1.77, p = 0.007), dominant model (OR = 1.32, p = 0.030), recessive (OR = 1.50, p = 0.047), over-dominant (OR = 1.34, p = 0.009), and allelic model (OR = 1.32, p = 0.004). Though our study showed the protective link of the TNF-alfa polymorphism to the preeclampsia risk among the Black population, no significant outcomes were observed in any genetic models (p > 0.05).
Overall, the present meta-analysis explored a consistent linkage of the TNF-alfa rs1800629 variant to the preeclampsia risk in different ethnic groups. Additional research is required to confirm the precise relationship between the rs1800629 variant and preeclampsia risk.
子痫前期是一种严重的医学疾病，对孕妇有重大影响。越来越多的研究表明，TNF-alfa rs1800629 多态性与子痫前期之间存在不一致的关联。本次荟萃分析旨在研究 rs1800629 变异与子痫前期之间的潜在影响。
系统检索了 Cochrane 图书馆、Google Scholar、PubMed、EMBASE、Web of Science 及其他数据库，以获取截至 2023 年 10 月 30 日的相关文章，并进行了筛选。本研究遵循 PRISMA 2020 建议进行。数据分析采用 Comprehensive Meta analysis (v 3) 软件进行。
本研究共纳入 32 篇文章，包含 35 项研究，共纳入 3883 例患者和 5821 例对照进行定性和定量数据分析。我们发现 rs1800629 变异与子痫前期风险增加之间存在显著关联，在共显性模型 1（OR=1.33，p=0.019）、共显性模型 2（OR=1.43，p=0.014）、显性模型（OR=1.25，p=0.044）、超显性模型（OR=1.31，p=0.021）和等位基因模型（OR=1.24，p=0.018）中均如此。本研究还表明，在亚洲人群中，显性模型（OR=2.31，p=0.036）和等位基因模型（OR=2.02，p=0.028）中，这种关联的风险显著更高。对于高加索人群，rs1800629 变异与子痫前期风险之间的关联在共显性模型 1（OR=1.37，p=0.011）、共显性模型 2（OR=1.77，p=0.007）、显性模型（OR=1.32，p=0.030）、隐性模型（OR=1.50，p=0.047）、超显性模型（OR=1.34，p=0.009）和等位基因模型（OR=1.32，p=0.004）中均有所报道。虽然我们的研究表明 TNF-alfa 多态性与黑人子痫前期风险之间存在保护关联，但在任何遗传模型中均未观察到显著结果（p>0.05）。
总体而言，本荟萃分析探讨了 TNF-alfa rs1800629 变异与不同人群子痫前期风险之间的一致关联。需要进一步的研究来确认 rs1800629 变异与子痫前期风险之间的精确关系。
