Brain network alterations in anorexia Nervosa: A Multi-Center structural connectivity study.

Anorexia nervosa (AN) is a severe eating disorder characterized by intense fear of weight gain, distorted body image, and extreme food restriction. This research employed advanced diffusion MRI techniques including single-shell 3-tissue constrained spherical deconvolution, anatomically constrained tractography, and spherical deconvolution informed filtering of tractograms to analyze brain network alterations in AN. Diffusion MRI data from 81 AN patients and 98 healthy controls were obtained. The structural brain connectome was constructed based on nodes set in 84 brain regions, and graph theory analysis was conducted. Results showed that AN patients exhibited significantly higher clustering coefficient and local efficiency in several brain regions, including the left fusiform gyrus, bilateral orbitofrontal cortex, right entorhinal cortex, right lateral occipital gyrus, right superior temporal gyrus, and right insula. A trend towards higher global efficiency and small-worldness was also observed in AN patients, although not statistically significant. These findings suggest increased local connectivity and efficiency within regions associated with behavioral rigidity, emotional regulation, and disturbed body image among AN patients. This study contributes to the understanding of the neurological basis of AN by highlighting structural connectivity alterations in specific brain regions.