Kanzawa Jun, Kurokawa Ryo, Takamura Tsunehiko, Nohara Nobuhiro, Kamiya Kouhei, Moriguchi Yoshiya, Sato Yasuhiro, Hamamoto Yumi, Shoji Tomotaka, Muratsubaki Tomohiko, Sugiura Motoaki, Fukudo Shin, Hirano Yoshiyuki, Sudo Yusuke, Kamashita Rio, Hamatani Sayo, Numata Noriko, Matsumoto Koji, Shimizu Eiji, Kodama Naoki, Kakeda Shingo, Takahashi Masatoshi, Ide Satoru, Okada Kazumasa, Takakura Shu, Gondo Motoharu, Yoshihara Kazufumi, Isobe Masanori, Tose Keima, Noda Tomomi, Mishima Ryo, Kawabata Michiko, Noma Shun'ichi, Murai Toshiya, Yoshiuchi Kazuhiro, Sekiguchi Atsushi, Abe Osamu
Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Neuroimage Clin. 2025;45:103737. doi: 10.1016/j.nicl.2025.103737. Epub 2025 Jan 29.
Anorexia nervosa (AN) is a severe eating disorder characterized by intense fear of weight gain, distorted body image, and extreme food restriction. This research employed advanced diffusion MRI techniques including single-shell 3-tissue constrained spherical deconvolution, anatomically constrained tractography, and spherical deconvolution informed filtering of tractograms to analyze brain network alterations in AN. Diffusion MRI data from 81 AN patients and 98 healthy controls were obtained. The structural brain connectome was constructed based on nodes set in 84 brain regions, and graph theory analysis was conducted. Results showed that AN patients exhibited significantly higher clustering coefficient and local efficiency in several brain regions, including the left fusiform gyrus, bilateral orbitofrontal cortex, right entorhinal cortex, right lateral occipital gyrus, right superior temporal gyrus, and right insula. A trend towards higher global efficiency and small-worldness was also observed in AN patients, although not statistically significant. These findings suggest increased local connectivity and efficiency within regions associated with behavioral rigidity, emotional regulation, and disturbed body image among AN patients. This study contributes to the understanding of the neurological basis of AN by highlighting structural connectivity alterations in specific brain regions.
神经性厌食症（AN）是一种严重的饮食失调症，其特征是强烈害怕体重增加、身体形象扭曲以及极端的食物限制。本研究采用了先进的扩散磁共振成像（MRI）技术，包括单壳三组织约束球面反卷积、解剖学约束纤维束成像以及基于球面反卷积的纤维束图滤波，以分析神经性厌食症患者的脑网络改变。获取了81名神经性厌食症患者和98名健康对照者的扩散MRI数据。基于84个脑区设定的节点构建了脑结构连接组，并进行了图论分析。结果显示，神经性厌食症患者在几个脑区表现出显著更高的聚类系数和局部效率，这些脑区包括左侧梭状回、双侧眶额皮质、右侧内嗅皮质、右侧枕外侧回、右侧颞上回和右侧岛叶。在神经性厌食症患者中还观察到整体效率和小世界特性有升高的趋势，尽管未达到统计学显著水平。这些发现表明，神经性厌食症患者中与行为僵化、情绪调节和身体形象紊乱相关的脑区内局部连接性和效率增加。本研究通过突出特定脑区的结构连接改变，有助于理解神经性厌食症的神经学基础。
