Caredda F, Rossi E, d'Arminio Monforte A, Zampini L, Re T, Meroni B, Moroni M
J Infect Dis. 1985 May;151(5):925-8. doi: 10.1093/infdis/151.5.925.
Markers of hepatitis B virus (HBV) and delta agent were prospectively tested in sera of 107 intravenous drug abusers with acute hepatitis positive for hepatitis B surface antigen (HBsAg) associated with delta infection and compared with the findings in addicts with acute classical hepatitis B. On the basis of the presence and titer of IgM antibody to hepatitis B core antigen, 86 of the addicts with delta infection had simultaneously acquired HBV and delta agent, and 21 were chronic carriers of HBsAg experiencing acute delta superinfection. The frequencies of biphasic and severe hepatitis were significantly higher (P less than .05) in delta agent-infected patients than in controls, but the acute clinical and biochemical features of the two varieties of delta disease were not distinguishable. However, in analogy to the clinical outcome of classical hepatitis B, all patients with nonfatal acute HBV/delta coinfection had self-limited illness, whereas 20 of 21 HBsAg carriers superinfected by delta agent developed chronic active hepatitis.
对107例乙型肝炎表面抗原（HBsAg）阳性且伴有丁型感染的急性肝炎静脉注射吸毒者的血清进行前瞻性检测，以检测乙肝病毒（HBV）和丁型肝炎病毒标志物，并与急性典型乙型肝炎成瘾者的检测结果进行比较。根据乙肝核心抗原IgM抗体的存在情况和滴度，86例丁型感染成瘾者同时感染了HBV和丁型肝炎病毒，21例为HBsAg慢性携带者，发生急性丁型肝炎病毒重叠感染。丁型肝炎病毒感染患者的双相性肝炎和重症肝炎发生率显著高于对照组（P<0.05），但两种丁型肝炎疾病的急性临床和生化特征并无明显差异。然而，与典型乙型肝炎的临床结局类似，所有非致命性急性HBV/丁型肝炎病毒合并感染患者的病情均为自限性，而21例HBsAg携带者中有20例因丁型肝炎病毒重叠感染发展为慢性活动性肝炎。
