Mou Ananya Dutta, Ali Nurshad
Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, 3114, Bangladesh.
Sci Rep. 2025 Feb 1;15(1):3967. doi: 10.1038/s41598-025-88798-4.
Liver dysfunctions during pregnancy can either be pregnancy-specific or preexisting in acute or chronic form. Data on the prevalence of abnormal liver functions and dyslipidemia during pregnancy in Bangladesh are scarce since these tests are not typically done in routine prenatal screening. This study aims to investigate the prevalence of elevated liver enzymes and dyslipidemia and associated risk factors in a cohort of pregnant women in Bangladesh. This cross-sectional study included 194 pregnant women participants from different trimesters. A standardized questionnaire was used to collect baseline, demographic, and lifestyle data. Blood samples were collected from each participant to measure biochemical parameters such as liver enzymes (ALT and GGT), lipid profile (TC, TG, HDL-C, and LDL-C), glucose, and creatinine levels in the serum. Logistic regression analysis was applied to identify factors associated with liver dysfunction and lipid profile abnormalities. The average age of the participants was 25 ± 5 years. Overall, the prevalence of preeclampsia was 12.4%. Among participants, 27% had increased ALT levels, most in their third trimester, while 11.8% had elevated GGT levels, mostly in early pregnancy. 83.8% of the study subjects had general dyslipidemia, with the highest prevalence in the second trimester and 5.2% had mixed dyslipidemia. Several factors were significantly associated with ALT elevation, such as preeclampsia, elevated blood pressure, low HDL-C levels, high parity number, having a higher number of children, hypertensive disorders during pregnancy and inadequate knowledge about pregnancy diet. On the other hand, advanced maternal age, high gravidity, and mixed dyslipidemia were associated with elevated GGT levels. Conversely, age, hypertensive disorders during pregnancy, preeclampsia, and diabetes were associated with dyslipidemia. In conclusion, elevated levels of liver enzymes and an abnormal lipid profile are common among pregnant women in Bangladesh. Various factors are linked to abnormal liver enzymes and dyslipidemia in these participants. Monitoring liver function and lipid levels, along with proper prenatal care, can help reduce the risk of maternal and neonatal mortality.
孕期肝功能障碍可以是特定于妊娠的，也可以是以急性或慢性形式预先存在的。由于这些检测通常不在常规产前筛查中进行，孟加拉国孕期肝功能异常和血脂异常患病率的数据很稀少。本研究旨在调查孟加拉国一组孕妇中肝酶升高和血脂异常的患病率及相关危险因素。这项横断面研究纳入了来自不同孕期的194名孕妇参与者。使用标准化问卷收集基线、人口统计学和生活方式数据。从每位参与者采集血样，以测量血清中的生化参数，如肝酶（谷丙转氨酶和谷氨酰转肽酶）、血脂谱（总胆固醇、甘油三酯、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇）、血糖和肌酐水平。应用逻辑回归分析来确定与肝功能障碍和血脂谱异常相关的因素。参与者的平均年龄为25±5岁。总体而言，子痫前期的患病率为12.4%。在参与者中，27%的谷丙转氨酶水平升高，大多数在孕晚期，而11.8%的谷氨酰转肽酶水平升高，大多在孕早期。83.8%的研究对象存在一般血脂异常，在孕中期患病率最高，5.2%存在混合性血脂异常。几个因素与谷丙转氨酶升高显著相关，如子痫前期、血压升高、高密度脂蛋白胆固醇水平低、高胎次、子女数量较多、孕期高血压疾病以及对孕期饮食知识不足。另一方面，高龄产妇、高孕次和混合性血脂异常与谷氨酰转肽酶水平升高有关。相反，年龄、孕期高血压疾病、子痫前期和糖尿病与血脂异常有关。总之，肝酶水平升高和血脂谱异常在孟加拉国孕妇中很常见。这些参与者中各种因素与肝酶异常和血脂异常有关。监测肝功能和血脂水平，以及适当的产前护理，有助于降低孕产妇和新生儿死亡风险。
