Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, Bangladesh.
Department of Food Engineering and Tea Technology, Shahjalal University of Science and Technology, Sylhet, Bangladesh.
Expert Rev Endocrinol Metab. 2023 Sep-Nov;18(6):541-547. doi: 10.1080/17446651.2023.2272867. Epub 2023 Nov 28.
This study aimed to investigate the association between serum liver enzymes and the presence of metabolic syndrome (MetS) among Bangladeshi adults.
A total of 602 participants (424 males and 178 females) were enrolled in this cross-sectional study. Serum levels of liver enzymes (ALT, AST, GGT and ALP) and other biochemical parameters were measured by standard colorimetric methods. The relationship between liver enzymes and MetS was assessed by multivariable logistic regression models.
Overall, the prevalence of MetS was 34.9% among the participants. Of the four liver enzymes, the mean levels of serum ALT and GGT were significantly higher among subjects with MetS than those without MetS ( < 0.01). When liver enzyme levels were categorized into normal and elevated ranges, MetS and its component's prevalence was higher in the elevated group except for ALP. Serum ALT and GGT showed a significant relationship with the maximum components of MetS. According to the logistic regression analysis, elevated levels of ALT and GGT were significantly associated with the prevalence of MetS ( < 0.01 and < 0.001, respectively).
This study showed that elevated ALT and GGT levels were independently associated with MetS and its components.
本研究旨在探讨血清肝酶与孟加拉国成年人代谢综合征（MetS）之间的关系。
共纳入 602 名参与者（424 名男性和 178 名女性），进行横断面研究。采用标准比色法测定血清肝酶（ALT、AST、GGT 和 ALP）和其他生化参数。采用多变量 logistic 回归模型评估肝酶与 MetS 的关系。
总体而言，参与者中 MetS 的患病率为 34.9%。在这四种肝酶中，血清 ALT 和 GGT 的平均水平在患有 MetS 的患者中明显高于未患有 MetS 的患者（<0.01）。当将肝酶水平分为正常和升高范围时，除 ALP 外，升高组的 MetS 及其组成部分的患病率更高。血清 ALT 和 GGT 与 MetS 的最大组成部分呈显著相关。根据 logistic 回归分析，ALT 和 GGT 水平升高与 MetS 的患病率显著相关（<0.01 和 <0.001）。
本研究表明，ALT 和 GGT 水平升高与 MetS 及其成分独立相关。
