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局部麻醉药对心脏直视手术患者阿片类药物使用及恢复情况的影响:一项随机对照研究。

The effect of local anaesthetic agents on opioid use and recovery in patients undergoing open heart surgery: a randomized controlled study.

作者信息

Azizoğlu Hatice, Aşam Mehmet, Gürkan Zeynep, Bozkurt Yasemin, Demir Canan

机构信息

Faculty of Health Sciences, Nursing, Van Yüzüncü Yıl University, Van, Turkey.

Van Training and Research Hospital, Van, Turkey.

出版信息

BMC Cardiovasc Disord. 2025 Feb 1;25(1):72. doi: 10.1186/s12872-025-04493-2.

Abstract

BACKGROUND

After open heart surgery, patients experience high levels of pain at the sternotomy incision site and around the chest tube(s), affecting their recovery. This study was conducted to determine the effects of local anesthetic application around the sternotomy incision site and chest tube(s) on the amount of opioids used and recovery after surgery in patients undergoing open heart surgery.

METHODS

This randomized controlled experimental study was conducted with a total of 60 patients, with 30 patients in the experimental group and 30 patients in the control group. In the experimental group, LIDOFAST 40 mg/2 ml + 0.025 mg/2 ml, a local anesthetic agent, was applied to the postoperative sternotomy incision site and around the chest tube(s) in addition to routine treatment. Patients in the control group received only routine treatment. Data were collected using the "Descriptive Characteristics Form" and the "Postoperative Recovery Index".

RESULTS

It was observed that postoperative pain started later, opioid consumption decreased, and postoperative recovery was faster in the experimental group. As the number of chest tubes increased, recovery was delayed in all groups, and as the number of opioids used increased, postoperative recovery was negatively affected in the control group.

CONCLUSIONS

In this study, local anesthetic application to the sternotomy incision site and around the chest tubes after open heart surgery was found to reduce postoperative opioid consumption and positively affect recovery.

TRIAL REGISTRATION

Current Controlled Trials NCT06642077 (Retrospectively registered).

摘要

背景

心脏直视手术后,患者在胸骨切开术切口部位及胸管周围会经历高度疼痛,影响其恢复。本研究旨在确定在胸骨切开术切口部位及胸管周围应用局部麻醉剂对心脏直视手术患者术后阿片类药物使用量及恢复情况的影响。

方法

本随机对照实验研究共纳入60例患者,其中实验组30例,对照组30例。实验组在常规治疗基础上,于术后胸骨切开术切口部位及胸管周围应用利多卡因快速起效制剂40mg/2ml + 0.025mg/2ml。对照组仅接受常规治疗。使用“描述性特征表”和“术后恢复指数”收集数据。

结果

观察到实验组术后疼痛出现较晚,阿片类药物消耗量减少,术后恢复更快。随着胸管数量增加,所有组的恢复均延迟,且随着对照组阿片类药物使用量增加,术后恢复受到负面影响。

结论

在本研究中,发现心脏直视手术后在胸骨切开术切口部位及胸管周围应用局部麻醉剂可减少术后阿片类药物消耗,并对恢复产生积极影响。

试验注册

当前对照试验NCT06642077(回顾性注册)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27be/11786327/489965777c6e/12872_2025_4493_Fig1_HTML.jpg

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