Kadam Onkar, Dalai Swayamprava, Chauhan Bhawna, Guru Rashmi Ranjan, Mitra Subhodip, Raytekar Namita, Kumar Rahul
Biotechnology, Symbiosis Centre for Nanoscience and Nanotechnology, Symbiosis International (Deemed) University, Pune, IND.
School of Biotech Engineering and Food Technology, Chandigarh University, Chandigarh, IND.
Cureus. 2025 Mar 12;17(3):e80478. doi: 10.7759/cureus.80478. eCollection 2025 Mar.
The geriatric population, comprising ages 65 and above, encounters distinct health obstacles because of physiological changes and heightened vulnerability to diseases. New technologies are being investigated to tackle the intricate health requirements of this population. Recent advancements in probiotics and nanotechnology offer promising strategies to enhance geriatric health by improving nutrient absorption, modulating gut microbiota, and delivering targeted therapeutic agents. Probiotics play a crucial role in maintaining gut homeostasis, reducing inflammation, and supporting metabolic functions. However, challenges such as limited viability and efficacy in harsh gastrointestinal conditions hinder their therapeutic potential. Advanced nanotechnology can overcome these constraints by enhancing the efficacy of probiotics through nano-encapsulation, controlled delivery, and improvement of bioavailability. This review explores the synergistic potential of probiotics and advanced nanotechnology in addressing age-related health concerns. It highlights key developments in probiotic formulations, nano-based delivery systems, and their combined impact on gut health, immunity, and neuroprotection. The convergence of probiotics and nanotechnology represents a novel and transformative approach to promoting healthy aging, paving the way for innovative therapeutic interventions.
65岁及以上的老年人群由于生理变化和对疾病的易感性增加,面临着独特的健康障碍。目前正在研究新技术,以满足这一人群复杂的健康需求。益生菌和纳米技术的最新进展提供了有前景的策略,通过改善营养吸收、调节肠道微生物群和递送靶向治疗剂来增进老年人的健康。益生菌在维持肠道稳态、减轻炎症和支持代谢功能方面发挥着关键作用。然而,诸如在恶劣胃肠道条件下生存能力和功效有限等挑战阻碍了它们的治疗潜力。先进的纳米技术可以通过纳米包封、控释和提高生物利用度来增强益生菌的功效,从而克服这些限制。本综述探讨了益生菌和先进纳米技术在解决与年龄相关的健康问题方面的协同潜力。它强调了益生菌制剂、基于纳米的递送系统的关键进展,以及它们对肠道健康、免疫和神经保护的综合影响。益生菌和纳米技术的融合代表了一种促进健康老龄化的新颖且变革性的方法,为创新治疗干预铺平了道路。