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铟111对人淋巴细胞的毒性

Indium 111 toxicity in the human lymphocyte.

作者信息

Silberstein E B, Watson S, Mayfield G, Kereiakes J G, Bullock W

出版信息

J Lab Clin Med. 1985 May;105(5):608-12.

PMID:3989353
Abstract

Indium-labeled lymphocytes were examined for response to a variety of mitogens, ability to synthesize immunoglobulins, mitotic index, and presence of chromosome aberrations at a range of exposures from 0.2 to 500 muCi/10(8) cells. Results of all four tests were found to be abnormal when the lymphocytes were labeled with 111In activities well within those employed for diagnostic testing.

摘要

检测了铟标记淋巴细胞对多种有丝分裂原的反应、合成免疫球蛋白的能力、有丝分裂指数以及在0.2至500微居里/10⁸个细胞的一系列暴露剂量下染色体畸变的情况。当用铟-111标记淋巴细胞,且其活度完全在用于诊断检测的活度范围内时,发现所有这四项检测的结果均异常。

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