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使用低轮廓编织或激光切割支架治疗颅内动脉瘤的临床和血管造影结果:倾向评分匹配分析

Clinical and Angiographic Outcomes of Intracranial Aneurysms Treated with Low-Profile Braided or Laser-Cut Stents: A Propensity Score-Matched Analysis.

作者信息

Zhang Guosai, Shen Yunan, Zhao Linbo, Ni Heng, Jia Zhenyu, Cao Yuezhou, Lu Guangdong, Liu Xinglong, Wang Bin, Zhou Chun, Shi Haibin, Liu Sheng

机构信息

Department of Interventional Radiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.

Department of Interventional Radiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China; Department of Stroke Center, Affiliated Hospital of Nantong University, Nantong, China.

出版信息

World Neurosurg. 2025 Mar;195:123747. doi: 10.1016/j.wneu.2025.123747. Epub 2025 Feb 24.

Abstract

OBJECTIVE

To compare the embolization outcomes and complications of the LEO Baby and Neuroform Atlas stents in the endovascular treatment of intracranial wide-neck aneurysms.

METHODS

We identified patients with intracranial aneurysms treated with LEO Baby (n = 163) or Atlas (n = 65) stent-assisted coiling between October 2018 and February 2023. A retrospective analysis of demographics, aneurysm characteristics, embolization outcomes, and procedure-related complications was performed. Propensity score matching analysis with a ratio of 1:2 was used to balance the patient selection bias that existed between the 2 cohorts.

RESULTS

Compared to the Atlas cohort, the LEO Baby cohort had a higher rate of immediate successful embolization (95.6% vs. 78.5%, P < 0.001) and a lower rate of incomplete embolization at midterm follow-up (4.0% vs. 18.6%, P = 0.006), but there was no significant difference for either after matching for a 1:2 propensity score (P = 0.091 and P = 0.081, respectively). Procedure-related complications were 10.4% (17/163) in the LEO Baby cohort and 7.7% (5/65) in the Atlas cohort. At midterm angiographic follow-up, recanalization occurred in 0.8% (1/124) of the LEO Baby cohort and 4.7% (2/43) of the Atlas cohort. Complication and recanalization rates for both stents were not statistically different before (P = 0.701 and P = 0.332, respectively) and after (P > 0.999 and P > 0.999, respectively) propensity score matching.

CONCLUSIONS

Both LEO Baby and Atlas are safe and effective in the treatment of intracranial aneurysms, and they are similar in terms of aneurysm embolization outcomes and complication rates.

摘要

目的

比较LEO Baby支架和Neuroform Atlas支架在颅内宽颈动脉瘤血管内治疗中的栓塞效果及并发症。

方法

我们纳入了2018年10月至2023年2月期间接受LEO Baby支架(n = 163)或Atlas支架(n = 65)辅助弹簧圈栓塞治疗的颅内动脉瘤患者。对患者的人口统计学资料、动脉瘤特征、栓塞效果及与手术相关的并发症进行回顾性分析。采用1:2的倾向评分匹配分析来平衡两个队列之间存在的患者选择偏倚。

结果

与Atlas队列相比,LEO Baby队列的即刻成功栓塞率更高(95.6%对78.5%,P < 0.001),中期随访时不完全栓塞率更低(4.0%对18.6%,P = 0.006),但在进行1:2倾向评分匹配后,两者均无显著差异(分别为P = 0.091和P = 0.081)。LEO Baby队列与手术相关的并发症发生率为10.4%(17/163),Atlas队列为7.7%(5/65)。在中期血管造影随访中,LEO Baby队列的再通率为0.8%(1/124),Atlas队列为4.7%(2/43)。在倾向评分匹配前(分别为P = 0.701和P = 0.332)及匹配后(分别为P > 0.999和P > 0.999),两种支架的并发症和再通率均无统计学差异。

结论

LEO Baby支架和Atlas支架在颅内动脉瘤治疗中均安全有效,在动脉瘤栓塞效果和并发症发生率方面相似。

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