Micheleto Jose Pedro Cassemiro, Melo Karin Araujo, Veloso Felipe Camilo Santiago, Kassar Samir Buainain, Oliveira Michelle Jacintha Cavalcante
Graduate Program in Medical Sciences, Medical School, Federal University of Alagoas, Maceió, Alagoas, Brazil.
Trop Med Int Health. 2025 Apr;30(4):235-245. doi: 10.1111/tmi.14088. Epub 2025 Feb 2.
Chikungunya fever is a debilitating arthritic disease that can lead to atypical severe complications and sometimes be fatal. The risk factors for fatal outcomes of chikungunya fever have not been thoroughly studied. This systematic review and meta-analysis aimed to identify mortality risk factors in patients with chikungunya. These findings will aid clinicians in targeting high-risk groups with severe chikungunya for timely interventions, ultimately improving patient outcomes.
The objective of this study is to identify mortality risk factors in patients with chikungunya.
We conducted a systematic review and meta-analysis by searching the MEDLINE, Embase, Cochrane, BVS, BDTD and OpenGrey databases to identify eligible observational studies on patients with chikungunya. These studies analysed mortality risk factors, providing adjusted risk measures along with their corresponding confidence intervals (CIs). We estimated the pooled weighted mean difference and 95% CIs using a random-effects model, and the methodological quality was assessed using the Newcastle-Ottawa Scale.
Our search yielded a total of 334 records. After removing duplicates, we screened 275 records, reviewed 31 full articles and included seven studies in the systematic review and four in the meta-analysis, with a total of 220,215 patients and 908 fatal cases. Diabetes Mellitus (OR = 2.86, 95% CI 1.75-4.69), hypertension (OR = 3.10, 95% CI 2.02-4.77), age ≥ 60 years (OR = 19.49, 95% CI 1.98-191.88), chronic kidney disease (OR = 5.81, 95% CI 1.30-25.99), male sex (OR = 2.07, 95% CI 1.71-2.51) and vomiting (OR = 2.18, 95% CI 1.75-2.73) are significantly and positively associated with mortality in chikungunya.
Elderly men with chronic diseases have a higher risk of death from chikungunya; therefore, they deserve more careful evaluation.
基孔肯雅热是一种使人衰弱的关节炎疾病，可导致非典型严重并发症，有时甚至会致命。基孔肯雅热致死结局的风险因素尚未得到充分研究。本系统评价和荟萃分析旨在确定基孔肯雅热患者的死亡风险因素。这些发现将有助于临床医生针对患有严重基孔肯雅热的高危人群进行及时干预，最终改善患者预后。
本研究的目的是确定基孔肯雅热患者的死亡风险因素。
我们通过检索MEDLINE、Embase、Cochrane、BVS、BDTD和OpenGrey数据库进行了一项系统评价和荟萃分析，以确定关于基孔肯雅热患者的符合条件的观察性研究。这些研究分析了死亡风险因素，提供了调整后的风险测量值及其相应的置信区间（CIs）。我们使用随机效应模型估计合并加权平均差和95%置信区间，并使用纽卡斯尔-渥太华量表评估方法学质量。
我们的检索共得到334条记录。去除重复记录后，我们筛选了275条记录，阅读了31篇全文，并将7项研究纳入系统评价，4项研究纳入荟萃分析，共有220215例患者和908例死亡病例。糖尿病（OR = 2.86，95% CI 1.75 - 4.69）、高血压（OR = 3.10，95% CI 2.02 - 4.77）、年龄≥60岁（OR = 19.49，95% CI 1.98 - 191.88）、慢性肾脏病（OR = 5.81，95% CI 1.30 - 25.99）、男性（OR = 2.07，95% CI 1.71 - 2.51）和呕吐（OR = 2.18，95% CI 1.75 - 2.73）与基孔肯雅热患者的死亡率显著正相关。
患有慢性病的老年男性死于基孔肯雅热的风险更高；因此，他们值得更仔细的评估。
