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Proteins lead the way: JAK inhibitors as a new treatment option in toxic epidermal necrolysis.

作者信息

Klein Benjamin, Kahlenberg J Michelle, Gudjonsson Johann E

机构信息

Department of Dermatology, Allergology and Venereology, Leipzig University Medical Center, University of Leipzig, Leipzig, Germany.

Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, USA.

出版信息

Signal Transduct Target Ther. 2025 Feb 3;10(1):32. doi: 10.1038/s41392-024-02122-6.

DOI:10.1038/s41392-024-02122-6
PMID:39894857
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11788422/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/708d/11788422/54a45ac799a9/41392_2024_2122_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/708d/11788422/54a45ac799a9/41392_2024_2122_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/708d/11788422/54a45ac799a9/41392_2024_2122_Fig1_HTML.jpg

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Proteins lead the way: JAK inhibitors as a new treatment option in toxic epidermal necrolysis.蛋白质引领方向：JAK抑制剂作为中毒性表皮坏死松解症的一种新治疗选择。
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Immune-Mediated Toxic Epidermal Necrolysis.免疫介导的中毒性表皮坏死松解症
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Comparison of reporting of Stevens-Johnson syndrome and toxic epidermal necrolysis in association with selective COX-2 inhibitors.与选择性环氧化酶-2抑制剂相关的史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症报告情况的比较。
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本文引用的文献

1
Spatial proteomics identifies JAKi as treatment for a lethal skin disease.空间蛋白质组学鉴定 JAKi 是治疗致命皮肤病的方法。
Nature. 2024 Nov;635(8040):1001-1009. doi: 10.1038/s41586-024-08061-0. Epub 2024 Oct 16.
2
Multiomic single-cell sequencing defines tissue-specific responses in Stevens-Johnson syndrome and toxic epidermal necrolysis.多组学单细胞测序定义史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症中的组织特异性反应。
Nat Commun. 2024 Oct 8;15(1):8722. doi: 10.1038/s41467-024-52990-3.
3
Severe cutaneous adverse reactions.严重皮肤不良反应。
Nat Rev Dis Primers. 2024 Apr 25;10(1):30. doi: 10.1038/s41572-024-00514-0.
4
Systemic interventions for treatment of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome.全身性治疗史蒂文斯-约翰逊综合征（SJS）、中毒性表皮坏死松解症（TEN）和 SJS/TEN 重叠综合征。
Cochrane Database Syst Rev. 2022 Mar 11;3(3):CD013130. doi: 10.1002/14651858.CD013130.pub2.
5
Neutrophils initiate and exacerbate Stevens-Johnson syndrome and toxic epidermal necrolysis.中性粒细胞引发并加剧史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症。
Sci Transl Med. 2021 Jun 30;13(600). doi: 10.1126/scitranslmed.aax2398.