酒精使用与创伤性脑损伤之间的关系：孟德尔随机化研究证据

Relationship between alcohol use and traumatic brain injury: evidence from Mendelian randomization.

作者信息

Zhang Xiaohang, Wu Wenze, Zhou Guisheng, Huang Xi, Xu Min, Zhao Qiulong, Yan Hui

机构信息

School of Integrated Medicine, Nanjing University of Chinese Medicine, Nanjing, China.

Jiangsu Key Laboratory for High Technology Research of TCM Formulae, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.

出版信息

Brain Inj. 2025;39(7):610-617. doi: 10.1080/02699052.2025.2460740. Epub 2025 Feb 2.

DOI:10.1080/02699052.2025.2460740

PMID:39894956

Abstract

BACKGROUND

Observational studies suggest that alcohol consumption increases the risk of traumatic brain injury (TBI); however, the causality of this association remains unclear.

OBJECTIVES

This study aimed to identify which drinking pattern is the primary factor influencing TBI.

METHOD

Two-sample Mendelian randomization (MR) was used to assess whether drinking patterns (alcohol consumption, abuse, and intake frequency) are causally associated with TBI risk.

RESULTS

MR analysis revealed causal effects of alcohol intake frequency [odds ratio (OR) 0.806, 95% confidence interval (CI): 0.665-0.978, = 0.028, beta: -0.215, se: 0.098], alcohol drinks per week (OR 1.772, 95% CI: 1.140-2.753, = 0.011, beta: 0.572, se: 0.225), and alcohol abuse (OR 1.095, 95% CI: 1.006-1.192, = 0.035, beta: 0.091, se: 0.043) on TBI. Additionally, no causal effect of alcohol consumption (OR 0.730, 95% CI: 0.264-2.025, = 0.546, beta: -0.314, se: 0.520) or average monthly alcohol intake (OR 1.138, 95% CI: 0.805-1.609, = 0.463, beta: 0.130, se: 0.177) on TBI was observed. Similarly, the effects of TBI on alcohol intake were statistically non-significant.

CONCLUSION

Drinking patterns, including alcohol intake frequency and abuse, influence TBI, whereas TBI rarely influences drinking patterns.

摘要

背景

观察性研究表明，饮酒会增加创伤性脑损伤（TBI）的风险；然而，这种关联的因果关系仍不清楚。

目的

本研究旨在确定哪种饮酒模式是影响TBI的主要因素。

方法

采用两样本孟德尔随机化（MR）方法来评估饮酒模式（饮酒量、酗酒和饮酒频率）与TBI风险之间是否存在因果关系。

结果

MR分析显示饮酒频率[比值比（OR）0.806，95%置信区间（CI）：0.665 - 0.978，P = 0.028，β： - 0.215，标准误：0.098]、每周饮酒量（OR 1.772，95% CI：1.140 - 2.753，P = 0.011，β：0.572，标准误：0.225）和酗酒（OR 1.095，95% CI：1.006 - 1.192，P = 0.035，β：0.091，标准误：0.043）对TBI有因果效应。此外，未观察到饮酒量（OR 0.730，95% CI：0.264 - 2.025，P = 0.546，β： - 0.314，标准误：0.520）或平均每月饮酒量（OR 1.138，95% CI：0.805 - 1.609，P = 0.463，β：0.130，标准误：0.177）对TBI有因果效应。同样，TBI对饮酒量影响在统计学上无显著意义。