Key Laboratory of Advanced Textile Materials and Manufacturing Technology (ATMT), Ministry of Education, Department of Polymer Materials, Zhejiang Sci-Tech University, Hangzhou 310018, China.
J Mater Chem B. 2019 Oct 14;7(38):5789-5796. doi: 10.1039/c9tb01071h. Epub 2019 Sep 4.
Near-infrared (NIR) irradiation responsive drug delivery systems have many advantages, which have attracted extensive interest from researchers. In this study, a NIR-triggered drug release system was established by grafting upper critical solution temperature (UCST) polymers on the surface of hollow mesoporous silica nanoparticles (HMSNs) followed by treatment with the photothermal conversion agent indocyanine green (ICG). The as-prepared UCST polymers showed the clearing temperature of 45 °C, which were advantageous to serve as gatekeepers in the physiological environment (37 °C). Under NIR irradiation, the temperature of the solution was elevated above the clearing point due to the presence of ICG; consequently, the collapsed UCST polymer chains became more hydrophilic; this resulted in the exposure of the mesoporous channels of the HMSNs and achievement of a burst drug release. Moreover, this NIR-responsive delivery system showed good biocompatibility and high anticancer efficiency towards the MCF-7 cancer cells upon exposure to NIR irradiation. In addition, a synergistic effect of thermal and chemo treatment has been achieved by the application of NIR irradiation since cancer cells are more vulnerable to high temperatures than normal cells.
近红外（NIR）光响应药物递送系统具有许多优点，引起了研究人员的广泛关注。在本研究中，通过在中空介孔硅纳米粒子（HMSNs）表面接枝上临界溶液温度（UCST）聚合物，并用光热转换剂吲哚菁绿（ICG）进行处理，构建了一种 NIR 触发的药物释放系统。所制备的 UCST 聚合物的澄清温度为 45°C，有利于在生理环境（37°C）中作为守门员。在 NIR 照射下，由于 ICG 的存在，溶液温度升高到澄清点以上；因此，UCST 聚合物链的坍塌变得更加亲水；这导致 HMSNs 的介孔通道暴露，并实现了药物的爆发式释放。此外，该 NIR 响应性递送系统在暴露于 NIR 照射下对 MCF-7 癌细胞表现出良好的生物相容性和高抗癌效率。此外，由于癌细胞比正常细胞对高温更敏感，因此应用 NIR 照射已实现了热疗和化疗的协同作用。
