Vilimelis-Piulats Ingrid, Pérez-Ricart Ariadna, Peligero Maite Bosch, Calvo Albert, Negre Josep Maria Suñé, Juárez-Gimenez Juan-Carlos
University of Barcelona (Faculty of Pharmacy and Food Sciences Campus Diagonal), Barcelona, Spain.
Hospital Universitari Germans Trias i Pujol (Pharmacy department). Badalona, Barcelona, Spain.
Br J Clin Pharmacol. 2025 Jun;91(6):1760-1770. doi: 10.1111/bcp.16392. Epub 2025 Feb 3.
The paediatric population is vulnerable to suffering adverse drug events (ADEs) such as negative outcomes due to medication (NOMs)-drug related problems (DRPs), especially adverse drug reactions (ADRs) and medication errors (MEs). Social media (SM) is considered an interesting tool for pharmacovigilance. This study aims to assess descriptions of ADRs, NOM-DRPs and MEs in SM.
Observational, ambispective study assessing NOM-DRPs, ADRs and MEs in posts of child-rearing public parenting forums from inception until December 2021 of drugs dispensed in outpatient setting. ADEs were classified, assessing causality by Liverpool Causality Assessment Tool and seriousness by the World Health Organization criteria. Summary of product characteristics were used to determine ADR prevalence.
In total, 3573 posts of 2 child-rearing public parenting forums were retrieved; 906 (25%) contained descriptions of medicine of which 823 (91%) were analysed; 425 posts (52%) described 636 NOM-DRPs (1 NOM-DRP median per child, interquartile range [IQR] 1-8), from which 161 (26%) were ADRs in 105 posts (1.5 ADR median per child, IQR 1-4) and 95 (15%) were MEs in 64 posts (1 ME median per child, IQR 1-4). From posts mined with medicines mentions, 70% included NOM-DRPs, 18% ADRs and 10% MEs. More ADRs occurred in females and infants. Most ADRs (158; 98%) were evaluated as possible and 17 ADRs (11%) were serious. Uncommon 19 (12%), (14, 9%), very rare (3, 2%) and rare (1, 1%) ADRs were also found.
Results suggest that information retrieved from SM may be useful to assess paediatric ADEs and provide valuable pharmacovigilance complementary data.
儿科人群易遭受药物不良事件（ADEs），如因用药导致的负面结果（NOMs）-药物相关问题（DRPs），尤其是药物不良反应（ADRs）和用药错误（MEs）。社交媒体（SM）被认为是药物警戒的一个有趣工具。本研究旨在评估社交媒体中ADRs、NOM-DRPs和MEs的描述。
采用观察性、双向性研究，评估从设立至2021年12月在门诊配发药物的育儿公共育儿论坛帖子中的NOM-DRPs、ADRs和MEs。对ADEs进行分类，采用利物浦因果关系评估工具评估因果关系，采用世界卫生组织标准评估严重程度。使用药品说明书摘要确定ADR发生率。
共检索到2个育儿公共育儿论坛的3573个帖子；906个（25%）包含药物描述，其中823个（91%）进行了分析；425个帖子（52%）描述了636个NOM-DRPs（每个儿童中位数1个NOM-DRP，四分位间距[IQR]1-8），其中161个（26%）是105个帖子中的ADRs（每个儿童中位数1.5个ADR，IQR 1-4），95个（15%）是64个帖子中的MEs（每个儿童中位数1个ME，IQR 1-4）。在提及药物的帖子中，70%包括NOM-DRPs，18%包括ADRs，10%包括MEs。女性和婴儿发生的ADRs更多。大多数ADRs（158个；98%）被评估为可能，17个ADRs（11%）为严重。还发现了不常见的ADRs 19个（12%）、（14个，9%）、非常罕见的（3个，2%）和罕见的（1个，1%）。
结果表明，从社交媒体检索到的信息可能有助于评估儿科ADEs，并提供有价值的药物警戒补充数据。
