Marklund S L, Adolfsson R, Gottfries C G, Winblad B
J Neurol Sci. 1985 Mar;67(3):319-25. doi: 10.1016/0022-510x(85)90156-x.
CuZn superoxide dismutase and Mn superoxide dismutase were analysed in hypothalamus, nucleus caudatus, hippocampus and cortex gyrus cinguli from 14 patients with dementia of Alzheimer type and from 16 controls. Ample amounts of both enzymes were demonstrated in the brains and there was little difference between the various parts of the brain. There were only small differences in the enzymic activities between the two groups indicating that deficiencies of these enzymes are not a very likely cause of brain degeneration in dementias of Alzheimer type.
对14例阿尔茨海默型痴呆患者和16例对照者的下丘脑、尾状核、海马和扣带回皮质中的铜锌超氧化物歧化酶和锰超氧化物歧化酶进行了分析。在大脑中发现了大量的这两种酶，并且大脑各部位之间差异不大。两组之间的酶活性只有微小差异，这表明这些酶的缺乏不太可能是阿尔茨海默型痴呆脑退化的原因。
