Oreland L, Wiberg A, Winblad B, Fowler C J, Gottfries C G, Kiianmaa K
J Neural Transm. 1983;56(1):73-83. doi: 10.1007/BF01243375.
The activity of monoamine oxidase--A was found to be lower in homogenates of hypothalamus and caudate nucleus, but not in cortex of the gyrus cinguli and hippocampus, from chronic alcoholics with respect to homogenates from autopsy cases without histories of alcohol abuse. The activity of monoamine oxidase--B was also lower in the alcoholics, but this could be due to the selective effect of age upon this enzyme form, since the alcoholics were younger than controls. No difference was found for either monoamine oxidase -A or -B activities in brain homogenates from an alcohol preferring (AA) strain of rats, with respect to those from a water preferring (ANA) strain.
与无酗酒史的尸检病例的匀浆相比，慢性酒精中毒者下丘脑和尾状核匀浆中的单胺氧化酶-A活性较低，但扣带回皮质和海马体中的单胺氧化酶-A活性并无差异。酒精中毒者的单胺氧化酶-B活性也较低，但这可能是由于年龄对这种酶形式的选择性影响，因为酒精中毒者比对照组年轻。与水偏好（ANA）品系大鼠的脑匀浆相比，酒精偏好（AA）品系大鼠的脑匀浆中，单胺氧化酶-A或-B活性均未发现差异。
