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癌症治疗后的心血管问题:证据空白与专家小组建议

Cardiovascular Considerations After Cancer Therapy: Gaps in Evidence and Expert Panel Recommendations.

作者信息

Blaes Anne, Nohria Anju, Armenian Saro, Bergom Carmen, Thavendiranathan Paaladinesh, Barac Ana, Sanchez-Petitto Gabriela, Desai Sanjal, Zullig Leah L, Morgans Alicia K, Herrmann Joerg

机构信息

Division of Hematology/Oncology/Transplantation, University of Minnesota, Minneapolis, Minnesota, USA.

Cardio-Oncology Program, Brigham and Women's Hospital, Boston, Massachusetts, USA.

出版信息

JACC CardioOncol. 2025 Jan 21;7(1):1-19. doi: 10.1016/j.jaccao.2024.06.006. eCollection 2025 Jan.

Abstract

Cancer survivors, particularly those treated with anthracyclines and chest radiation, face an elevated risk of cancer therapy-related cardiovascular toxicity. These complications affect not only physical health, but also life expectancy. Risk factors for cancer therapy-related cardiovascular toxicity include age at which cancer treatment was received, the use of (potentially) cardiotoxic cancer therapies, and the presence of concomitant cardiovascular risk factors. Current guidelines provide recommendations for cardiovascular surveillance after cancer therapy, including type and frequency. All cancer survivors are advised to undergo annual clinical screenings and optimization of cardiovascular risk factors. Those at higher risk should undergo additional cardiovascular testing. This document aims to summarize the available evidence, present practical recommendations, and outline existent gaps in the current literature regarding cardiovascular care after cancer therapies.

摘要

癌症幸存者,尤其是那些接受过蒽环类药物治疗和胸部放疗的患者,面临着癌症治疗相关心血管毒性风险升高的问题。这些并发症不仅影响身体健康,还会影响预期寿命。癌症治疗相关心血管毒性的风险因素包括接受癌症治疗时的年龄、使用(潜在)心脏毒性癌症治疗方法以及存在并存的心血管风险因素。现行指南提供了癌症治疗后心血管监测的建议,包括监测类型和频率。建议所有癌症幸存者每年进行临床筛查并优化心血管风险因素。高危人群应接受额外的心血管检查。本文旨在总结现有证据,提出实用建议,并概述当前文献中关于癌症治疗后心血管护理方面存在的差距。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2af4/11782100/4d8a8f2cfd05/ga1.jpg

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