Varma Sudhir R, Ani Omar H A A, Narayanan Jayaraj K, Mathew Asok
Department of Clinical Sciences, Ajman University, Ajman, United Arab Emirates.
Center for Medical and bio-allied health Sciences Research, Ajman University, Ajman, United Arab Emirates.
Front Oral Health. 2025 Jan 17;6:1540178. doi: 10.3389/froh.2025.1540178. eCollection 2025.
Periodontal disease is a widespread chronic inflammatory state influencing the supporting anatomy of the teeth, distinguished by oxidative stress, progressive bone loss, and tissue damage. Recent articles have highlighted the significance of mitochondrial dynamics, mainly Mitofusin-1 (MFN1) along with Mitofusin-2 (MFN2), inflammation regulation, tissue homeostasis, and in cellular function. The aim of the current study is to comprehensively review including evaluate the roles of MFN2 and MFN1 in the pathogenesis as well as the progression of periodontal disease, foregrounding their effect on mitochondrial integrity, inflammatory pathways, and oxidative stress. Studies were selected depending on inclusion criteria based on the roles of MFN2 and MFN1 in periodontal disease and health. Data from chosen , clinical studies, and were synthesized. Outcomes indicate that MFN2 and MFN1 are important for preserving cellular function, mitigating oxidative damage, and mitochondrial fusion. Decreased levels of these proteins were related to elevated oxidative stress, inflammation, and increased mitochondrial dysfunction in periodontal tissues. The current comprehensive review shows the important roles of MFN1 along with MFN2 in inflammation regulation, cell survival, and mitochondrial dynamics within periodontal disease. The prospective for targeting MFN1 along with MFN2 in therapeutic policy is promising, presenting avenues for upgraded periodontal management and regeneration.
牙周病是一种广泛存在的慢性炎症状态，影响牙齿的支持结构，其特征为氧化应激、进行性骨质流失和组织损伤。近期文章强调了线粒体动力学的重要性，主要是线粒体融合蛋白1（MFN1）和线粒体融合蛋白2（MFN2），以及炎症调节、组织稳态和细胞功能。本研究的目的是全面综述并评估MFN2和MFN1在牙周病发病机制及进展中的作用，突出它们对线粒体完整性、炎症途径和氧化应激的影响。根据MFN2和MFN1在牙周病与健康中的作用，依据纳入标准选择研究。对所选的临床研究等数据进行了综合分析。结果表明，MFN2和MFN1对于维持细胞功能、减轻氧化损伤和线粒体融合很重要。这些蛋白质水平的降低与牙周组织中氧化应激升高、炎症增加以及线粒体功能障碍加剧有关。当前的全面综述显示了MFN1和MFN2在牙周病炎症调节、细胞存活和线粒体动力学中的重要作用。在治疗策略中靶向MFN1和MFN2的前景很有希望，为改善牙周管理和再生提供了途径。
