Eller M G, Schoenwald R D, Dixson J A, Segarra T, Barfknecht C F
J Pharm Sci. 1985 Feb;74(2):155-60. doi: 10.1002/jps.2600740210.
An analogue series representing modification to the benzene ring of ethoxzolamide has been evaluated for solubility, pKa, partitioning, and permeability across excised rabbit corneas. These physical parameters were correlated to Hammett sigma (para) and/or Hansch pi parameter values for each compound. From these correlations, a mathematical model was developed relating corneal permeability to molecular modifications of ethoxzolamide. A three-dimensional plot of maximum attainable penetration rate versus sigma (para) and pi yielded an optimal range of pi and sigma values from which an optimally penetrating analogue could be designed.
已经评估了一系列代表乙氧唑胺苯环修饰的类似物在溶解度、pKa、分配系数以及对离体兔角膜的渗透性方面的表现。这些物理参数与每种化合物的哈米特σ（对位）和/或汉施π参数值相关。基于这些相关性，建立了一个将角膜渗透性与乙氧唑胺分子修饰相关联的数学模型。以最大可达到的渗透速率对σ（对位）和π作三维图，得出了π和σ值的最佳范围，据此可以设计出具有最佳渗透性的类似物。
