Hatzl Stefan, Geiger Christina, Kriegl Lisa, Reinisch Andreas, Wölfler Albert, Apfaltrer Georg, Keldorfer Markus, Rödl Siegfried, Hoenigl Martin, Eller Philipp, Krause Robert
Department of Internal Medicine, Intensive Care Unit, Medical University of Graz, Graz, Austria.
BioTechMed-Graz, Graz, Austria.
Open Forum Infect Dis. 2025 Jan 13;12(2):ofaf018. doi: 10.1093/ofid/ofaf018. eCollection 2025 Feb.
In this multicenter study of 387 patients who were immunocompromised, 4.5% with invasive pulmonary aspergillosis also had pneumonia. Predictors of coinfection included elevated β-D-glucan and prolonged corticosteroid use. Coinfection correlated with reduced 30-day survival (22% vs 57%), suggesting that early identification and prophylaxis may improve outcomes.
在这项针对387名免疫功能低下患者的多中心研究中,4.5%的侵袭性肺曲霉病患者同时患有肺炎。合并感染的预测因素包括β-D-葡聚糖升高和长期使用皮质类固醇。合并感染与30天生存率降低相关(22%对57%),这表明早期识别和预防可能改善预后。