Demircioğlu Mahmut Kaan, Sari Serkan, Korkmaz Mehmet Saban, Yildiz Gorkem, Akbulut Sezer, Matlim Ozel Tugba, Soytas Yigit
Surgical Oncology, Basaksehir Cam and Sakura City Hospital, Istanbul, TUR.
General Surgery, Basaksehir Cam and Sakura City Hospital, Istanbul, TUR.
Cureus. 2025 Jan 2;17(1):e76801. doi: 10.7759/cureus.76801. eCollection 2025 Jan.
Background Papillary thyroid cancer (PTC) is one of the most common cancers with a favorable prognosis. The prognosis is most commonly associated with lymph node metastasis. We investigated whether there is a relationship between the hemoglobin, albumin, lymphocyte, and platelet (HALP) score and PTC central region lymph node metastasis in the preoperative period. NLR (neutrophil/lymphocyte ratio), PLR (platelet/lymphocyte ratio), MLR (monocyte/lymphocyte ratio), PIV (pan-immune-inflammation value), PNI (prognostic nutritional index), SII (systemic immune-inflammation index) were analyzed as other predictive factors for PTC central region lymph node metastasis. Methods The data of 235 patients who were operated on for PTC and underwent additional central neck dissection in our clinic were analyzed retrospectively. The effect of the HALP score, NLR, PLR, MLR, PIV, PNI, and SII values on PTC central region lymph node metastasis was analyzed with univariate and multiple logistic regression analyses. Results The HALP score, NLR, PLR, MLR, PIV, PNI, and SII had no statistically significant effect on the number of positive lymph nodes in the central region, lymphatic invasion, vascular invasion, extra-thyroidal invasion in PTC (p>0.050 for each). For PTC, stage progression was associated with a decrease in preoperative PNI (OR=0.871; p=0.019). Conclusion There was a significant negative correlation between PNI and the stage of the PTC. No significant correlation was found between the HALP score and prognostic predictors of papillary PTC central lymph node metastasis. This may be related to the fact that PTC is a type of cancer that does not affect biochemical parameters much.
背景 甲状腺乳头状癌（PTC）是最常见的癌症之一，预后良好。其预后最常与淋巴结转移相关。我们调查了术前血红蛋白、白蛋白、淋巴细胞和血小板（HALP）评分与PTC中央区淋巴结转移之间是否存在关联。分析中性粒细胞/淋巴细胞比值（NLR）、血小板/淋巴细胞比值（PLR）、单核细胞/淋巴细胞比值（MLR）、全免疫炎症值（PIV）、预后营养指数（PNI）、全身免疫炎症指数（SII）作为PTC中央区淋巴结转移的其他预测因素。方法 回顾性分析在我院接受PTC手术并进行额外中央区颈清扫的235例患者的数据。采用单因素和多因素logistic回归分析HALP评分、NLR、PLR、MLR、PIV、PNI和SII值对PTC中央区淋巴结转移的影响。结果 HALP评分、NLR、PLR、MLR、PIV、PNI和SII对PTC中央区阳性淋巴结数量、淋巴管侵犯、血管侵犯、甲状腺外侵犯均无统计学显著影响（每项p>0.050）。对于PTC，分期进展与术前PNI降低相关（OR=0.871；p=0.019）。结论 PNI与PTC分期之间存在显著负相关。未发现HALP评分与甲状腺乳头状癌中央区淋巴结转移的预后预测指标之间存在显著相关性。这可能与PTC是一种对生化参数影响不大的癌症这一事实有关。
