Zhu Yanlun, Zhang Xuerao, Chang Guozhu, Deng Shuai, Chan Hon Fai
Key Laboratory for Regenerative Medicine of the Ministry of Education of China, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, P. R. China.
Institute for Tissue Engineering and Regenerative Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, P. R. China.
Adv Mater. 2025 Jan;37(2):e2312964. doi: 10.1002/adma.202312964. Epub 2024 Jul 16.
Bioactive glass (BG) is a class of biocompatible, biodegradable, multifunctional inorganic glass materials, which is successfully used for orthopedic and dental applications, with several products already approved for clinical use. Apart from exhibiting osteogenic properties, BG is also known to be angiogenic and antibacterial. Recently, BG's role in immunomodulation has been gradually revealed. While the therapeutic effect of BG is mostly reported in the context of bone and skin-related regeneration, its application in regenerating other tissues/organs, such as muscle, cartilage, and gastrointestinal tissue, has also been explored recently. The strategies of applying BG have also expanded from powder or cement form to more advanced strategies such as fabrication of composite polymer-BG scaffold, 3D printing of BG-loaded scaffold, and BG-induced extracellular vesicle production. This review presents a concise overview of the recent applications of BG in regenerative medicine. Various regenerative strategies of BG will be first introduced. Next, the applications of BG in regenerating various tissues/organs, such as bone, cartilage, muscle, tendon, skin, and gastrointestinal tissue, will be discussed. Finally, clinical applications of BG for tissue regeneration will be summarized, and future challenges and directions for the clinical translation of BG will be outlined.
生物活性玻璃（BG）是一类具有生物相容性、可生物降解的多功能无机玻璃材料，已成功应用于骨科和牙科领域，有多种产品已获临床使用批准。除了具有成骨特性外，BG还具有促血管生成和抗菌作用。最近，BG在免疫调节中的作用也逐渐显现出来。虽然BG的治疗效果大多是在与骨骼和皮肤相关的再生背景下报道的，但最近也有人探索了其在再生其他组织/器官（如肌肉、软骨和胃肠道组织）中的应用。BG的应用策略也从粉末或水泥形式扩展到了更先进的策略，如复合聚合物 - BG支架的制备、载BG支架的3D打印以及BG诱导的细胞外囊泡生成。本文综述简要概述了BG在再生医学中的最新应用。首先将介绍BG的各种再生策略。接下来，将讨论BG在再生各种组织/器官（如骨骼、软骨、肌肉、肌腱、皮肤和胃肠道组织）中的应用。最后，将总结BG在组织再生方面的临床应用，并概述BG临床转化面临的未来挑战和方向。
