Núñez Sonia, Millán-Laleona Adrián, Cano-Lou Javier, Corella Andrea, Moliner Cristina, Cásedas Guillermo, Maggi Filippo, López Víctor, Gómez-Rincón Carlota
Department of Pharmacy, Faculty of Health Sciences, Universidad San Jorge, Villanueva de Gállego, 50830, Zaragoza, Spain.
Instituto Agroalimentario de Aragón-IA2, CITA-Universidad de Zaragoza, 50013, Zaragoza, Spain.
Heliyon. 2025 Jan 11;11(2):e41898. doi: 10.1016/j.heliyon.2025.e41898. eCollection 2025 Jan 30.
Black mulberries have been traditionally used as antidiabetic agents and are a source of nutrients and phenolic compounds, particularly anthocyanins. The objective of this work is to determine if berries could prevent metabolic and obesity-related disorders using systems and alternative models such as . An aqueous solvent-free extract from fruits rich in phenolic compounds like chlorogenic acid, hyperoside, rutin and cyanidin 3-glucoside was evaluated in the obese model subjected to high glucose concentrations evaluating different parameters such as lipid droplets, lipofuscin accumulation and ROS production. The capacity of the extract to inhibit advance glycation end products and free radicals as well as pancreatic lipase and α-amylase was also evaluated . The black mulberry extract showed a significant capacity to inhibit the accumulation of lipid droplets, reducing by 50.40 % the fat deposits. The extract was able to reverse the deleterious effects of excess glucose in enhancing stress resistance, preventing the accumulation of lipofuscin, and decreasing the ROS production. The anti-glycation and antioxidant effects were higher than the reference substances aminoguanidine and quercetin respectively. was also able to inhibit the pancreatic enzymes α-amylase and lipase and could be considered an interesting traditional food ingredient in the prevention of certain metabolic diseases.
黑桑椹传统上被用作抗糖尿病药物，是营养物质和酚类化合物的来源，尤其是花青素。这项工作的目的是使用……等系统和替代模型来确定黑桑椹是否可以预防代谢和肥胖相关疾病。在高葡萄糖浓度的肥胖模型中，对富含酚类化合物（如绿原酸、金丝桃苷、芦丁和矢车菊素3 - 葡萄糖苷）的黑桑椹果实的无水溶液提取物进行了评估，评估了不同参数，如脂滴、脂褐素积累和活性氧生成。还评估了该提取物抑制晚期糖基化终产物和自由基以及胰脂肪酶和α -淀粉酶的能力。黑桑椹提取物显示出显著的抑制脂滴积累的能力，脂肪沉积减少了50.40%。该提取物能够逆转高糖在增强应激抗性、防止脂褐素积累和减少活性氧生成方面的有害影响。其抗糖基化和抗氧化作用分别高于参考物质氨基胍和槲皮素。它还能够抑制胰腺酶α -淀粉酶和脂肪酶，可被认为是预防某些代谢疾病的一种有趣的传统食品成分。
