Adib Ahmed Ahsan, Karim Muhammad Manjurul
Department of Microbiology, University of Dhaka, Dhaka, 1100, Bangladesh.
Heliyon. 2025 Jan 10;11(2):e41824. doi: 10.1016/j.heliyon.2025.e41824. eCollection 2025 Jan 30.
Emergence of the Chikungunya virus (CHIKV) is a new threat in the world. The disastrous effect of this virus and the unavailability of specific drugs complicated the control and management of the disease. The development of a siRNA-based drug using multiple computational tools could be a way out as one of its therapeutics. Currently, very few siRNAs against CHIKV have been computationally designed and published. Here, we considered various parts of the CHIKV genome encoding different essential protein-coding genes for designing siRNAs with a view to silencing them, thereby rendering the virus inactive. Seven potential primary siRNAs were constructed, of which, five are hereafter recommended to be used as a therapeutic tool against the virus.
基孔肯雅病毒（CHIKV）的出现是全球面临的新威胁。该病毒造成的灾难性影响以及缺乏特效药物，使疾病的控制和管理变得复杂。利用多种计算工具开发基于小干扰RNA（siRNA）的药物可能是一种治疗方法。目前，通过计算设计并发表的针对CHIKV的siRNA非常少。在此，我们考虑了CHIKV基因组中编码不同必需蛋白质编码基因的各个部分，以设计siRNA来沉默这些基因，从而使病毒失去活性。我们构建了7种潜在的初级siRNA，其中5种在此推荐作为对抗该病毒的治疗工具。
