Hoseini Rastegar, Hoseini Zahra, Kamangar Ayob
Assistant Professor of Exercise Physiology, Department of Exercise Physiology, Faculty of Sport Sciences, Razi University, Kermanshah, Iran.
PhD of Exercise Physiology, Department of Exercise Physiology, Faculty of Sport Sciences, Razi University, Kermanshah, Iran.
Heliyon. 2025 Jan 10;11(2):e41888. doi: 10.1016/j.heliyon.2025.e41888. eCollection 2025 Jan 30.
Aerobic training induces a myriad of adaptations in muscle tissue, encompassing alterations in muscle fiber type composition, hypertrophy, and metabolic capacity. Understanding the potential role of myogenic differentiation markers (MDFs), such as Pax7, MyoD, Myogenin, and myosin heavy chain (MHC) isoforms, in mediating these adaptations is of paramount importance. The review delves into the intricate molecular mechanisms underlying the regulation of MDFs following aerobic training, elucidating the role of key signaling pathways including the MAPK/ERK, PI3K/Akt, and AMPK pathways, among others. These pathways play pivotal roles in orchestrating the expression and activity of MDFs, ultimately influencing muscle adaptation and regeneration. The comprehension of MDFs in the context of aerobic training is far-reaching, offering the potential for targeted interventions to optimize muscle adaptation and regeneration. This review identifies the need for further research to unveil the precise molecular mechanisms of the activation and interaction of myogenic differentiation markers with other signaling pathways, as well as to explore their potential as therapeutic targets for muscle-related conditions. This review article also provides a thorough analysis of MDFs in muscle tissue after aerobic training, highlighting their potential clinical implications and outlining future research directions in this area.
有氧训练会在肌肉组织中引发无数适应性变化，包括肌纤维类型组成的改变、肥大以及代谢能力的变化。了解生肌分化标志物（MDFs），如Pax7、MyoD、肌细胞生成素和肌球蛋白重链（MHC）亚型，在介导这些适应性变化中的潜在作用至关重要。这篇综述深入探讨了有氧训练后生肌分化标志物调控背后复杂的分子机制，阐明了包括MAPK/ERK、PI3K/Akt和AMPK等关键信号通路的作用。这些通路在协调生肌分化标志物的表达和活性方面发挥着关键作用，最终影响肌肉的适应性和再生。在有氧训练背景下对生肌分化标志物的理解意义深远，为优化肌肉适应性和再生的靶向干预提供了可能性。这篇综述指出需要进一步研究，以揭示生肌分化标志物激活及与其他信号通路相互作用的精确分子机制，以及探索它们作为肌肉相关疾病治疗靶点的潜力。这篇综述文章还对有氧训练后肌肉组织中的生肌分化标志物进行了全面分析，强调了它们潜在的临床意义，并概述了该领域未来的研究方向。
