Flintoff Jonathan M, Pattinson Cassandra, Ahamed Sarah, Ali Shahnewaz, Bagley Angus, Broszczak Daniel, Crewther Blair, de Waal Louis, Edmed Shannon L, Fernando Tharindu, Fookes Clinton, Frentiu Francesca D, Hunt Andrew P, Lipp Ottmar V, McMaster Ben, Mengersen Kerrie, Ney Luke, Oon Senn L, Pandey Ajay, Pandit Parth, Peake Jonathan M, Perera Muthukuttige Madusha Nuwanthi, Perlo Virginie, Punyadeera Chamindie, Schmidt Luke, Smith Simon S, Spann Kirsten, Stewart Ian, Sullivan Karen A, Young Danielle, Kerr Graham, Parker Tony J
School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.
Centre for Biomedical Technologies, Queensland University of Technology, Brisbane, Queensland, Australia.
BMJ Open Sport Exerc Med. 2025 Jan 20;11(1):e002410. doi: 10.1136/bmjsem-2024-002410. eCollection 2025.
Understanding and predicting individual responses to common stressors is essential for optimising performance in high-stress environments. This article outlines a protocol for a study to identify biomarkers that predict performance under heat, musculoskeletal, psychosocial and sleep stress, for future integration into a wearable sensor system. In Phase I, healthy adults aged between 18 and 45 years (n=104) will be recruited for an intervention trial that involves exposure to one of the four stressors: heat, musculoskeletal, psychosocial or sleep deprivation. Biomarkers will be identified from molecular markers in biological samples (eg, blood, saliva, sweat and stool), physiological measures and psychological assessments to predict cognitive and physical performance under stress. A within-subjects design will determine changes in molecular and non-molecular markers before and after stress exposure. In Phase II, we will use the biomarkers identified in Phase I to develop a wearable sensor to predict and monitor human performance under stress.
了解和预测个体对常见压力源的反应对于在高压力环境中优化表现至关重要。本文概述了一项研究方案，旨在识别能够预测在热、肌肉骨骼、心理社会和睡眠压力下表现的生物标志物，以便未来整合到可穿戴传感器系统中。在第一阶段，将招募18至45岁的健康成年人（n = 104）参与一项干预试验，该试验涉及暴露于四种压力源之一：热、肌肉骨骼、心理社会或睡眠剥夺。将从生物样本（如血液、唾液、汗液和粪便）中的分子标记、生理测量和心理评估中识别生物标志物，以预测压力下的认知和身体表现。受试者内设计将确定压力暴露前后分子和非分子标记的变化。在第二阶段，我们将使用在第一阶段识别出的生物标志物来开发一种可穿戴传感器，以预测和监测压力下的人类表现。
