Im Yeon Hee, Kim Dong-Hyun, Lee Seulah, Jeon Eun-Ju, Nam Inn-Chul, Lee Hyun Jin, Kim Dae-Yang
Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea, Uijeongbu-si, Gyeonggi-do, 11765, Republic of Korea.
Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea, 56, Dongsu-ro, Bupyeong-gu, Incheon, 21431, Republic of Korea.
Eur Arch Otorhinolaryngol. 2025 Apr;282(4):1929-1939. doi: 10.1007/s00405-025-09241-y. Epub 2025 Feb 3.
Obstructive sleep apnea (OSA) is a prevalent disorder associated with severe comorbidities. Anatomical variations, including nasal diseases, have been identified as potential contributing factors. This study aimed to explore the relationship between nasal cross-sectional areas (CSAs) and OSA, using both acoustic rhinometry (AR) and computed tomography (CT).
A retrospective analysis was conducted on 355 individuals who underwent polysomnography (PSG), paranasal sinus CT, and AR. Clinical characteristics were compared among the non-OSA, mild OSA, moderate OSA, and severe OSA patients. Multiple logistic regression was used to determine the influence of nasal cross-sectional areas (CSAs) on the risk of developing moderate or severe OSA, with adjustments for sex, age, and body mass index.
Significant associations between specific AR-measured CSA values of anterior nasal region and moderate-severe OSA were identified upon adjusting for confounders (p = 0.034, 0.010, and 0.025, respectively). The lower CSA measurements between the right and the left sides showed a stronger correlation with moderate-severe OSA than the summed values, suggesting the importance of the narrower nasal passage in OSA severity. No significant impact of CSA values on the development of severe OSA was observed.
Nasal CSA measured using AR appears to be a better method for verifying its association with OSA than CT. Nasal CSAs at the anterior region of the inferior turbinates play a crucial role in developing OSA, independent of other known risk factors.
阻塞性睡眠呼吸暂停（OSA）是一种常见疾病，与严重的合并症相关。包括鼻部疾病在内的解剖学变异已被确定为潜在的促成因素。本研究旨在使用鼻声反射（AR）和计算机断层扫描（CT）探索鼻横截面积（CSA）与OSA之间的关系。
对355例接受多导睡眠图（PSG）、鼻窦CT和AR检查的个体进行回顾性分析。比较非OSA、轻度OSA、中度OSA和重度OSA患者的临床特征。采用多因素logistic回归分析确定鼻横截面积（CSA）对发生中度或重度OSA风险的影响，并对性别、年龄和体重指数进行校正。
在校正混杂因素后，发现前鼻区域特定AR测量的CSA值与中度至重度OSA之间存在显著关联（分别为p = 0.034、0.010和0.025）。左右两侧较低的CSA测量值与中度至重度OSA的相关性比总和值更强，表明较窄的鼻道在OSA严重程度中的重要性。未观察到CSA值对重度OSA发生有显著影响。
与CT相比，使用AR测量的鼻CSA似乎是验证其与OSA关联的更好方法。下鼻甲前部区域的鼻CSA在OSA的发生中起关键作用，独立于其他已知风险因素。
