Kochneva A A, Kuritsin A E, Murzina S A
Institute of Biology, Karelian Research Center, Russian Academy of Sciences, Petrozavodsk, Russia.
Dokl Biol Sci. 2025 Feb;520(1):38-43. doi: 10.1134/S001249662460057X. Epub 2025 Jan 31.
Aquaculture is one of the main sources of fish products and ensures their sustainable growth on the global scale, exceeding industrial fishing. At the same time, integrated processing of aquaculture by-products is an important environmental and industrial problem. Valuable biological components might be found in fish processing wastes left after manufacturing the target products (fillet, offal, etc.). In particular, antimicrobial peptides that exhibit broad-spectrum antimicrobial activity are expressed in fish. A first exploratory analysis of rainbow trout Oncorhynchus mykiss brain proteins was performed to identify the theoretical antimicrobial patterns. More than half of the identified proteins were predicted to have antimicrobial regions. The proteins included histones, vitellogenin, collagen, etc. The results may be of interest for designing drugs based on peptides active against various pathogens. The field is of importance in view of the increasing antibiotic resistance of pathogenic microorganisms.
水产养殖是鱼类产品的主要来源之一，能确保其在全球范围内可持续增长，产量超过工业捕捞。与此同时，水产养殖副产品的综合加工是一个重要的环境和工业问题。在生产目标产品（鱼片、内脏等）后剩余的鱼类加工废料中可能会发现有价值的生物成分。特别是，鱼类中表达的抗菌肽具有广谱抗菌活性。对虹鳟鱼脑蛋白进行了首次探索性分析，以确定其理论抗菌模式。超过一半的已鉴定蛋白质预计具有抗菌区域。这些蛋白质包括组蛋白、卵黄蛋白原、胶原蛋白等。这些结果可能对设计基于对各种病原体有活性的肽的药物具有重要意义。鉴于致病微生物的抗生素耐药性不断增加，这一领域具有重要意义。
