Alahmari Mushabbab, Elsisi Hany Farid, Ismail Ali Mohamed Ali
Department of Respiratory Therapy, College of Applied Medical Sciences, University of Bisha, Bisha, Saudi Arabia.
Department of Physical Therapy for Cardiovascular/Respiratory Disorder and Geriatrics, Faculty of Physical Therapy, Cairo University, Cairo, Egypt.
Ir J Med Sci. 2025 Apr;194(2):761-769. doi: 10.1007/s11845-025-03876-w. Epub 2025 Feb 3.
Intensive care unit acquired-weakness syndrome (ICUAWS) leaves several complications in functional movements of patients such as severe walking disability.
Assessment of functional outcomes of 1-month inspiratory muscle training (IMT) in elderly with ICUAWS and severe walking disability was our aim. The design, setting, participants, and intervention. This study is a randomized controlled trial. ICUAWS patients who complained of severe walking disability on the Modified Functional Ambulatory Category Test (MFACT) were randomly assigned into the IMT group or control group, n = 20 for each group. Both groups received the traditional physical therapy program.
The results showed that the post-therapy between-group comparison of ICUAWS sufferers/groups' parameters showed a significant improvement toward the IMT group in six-minute walk test, inspiratory and expiratory muscle strength, forced vital capacity, time up and go test, 10-m walk test, forced expiratory volume in the first second, 30-s sit-to-stand test, partial pressure of arterial blood oxygen and carbon dioxide, MFACT, oxygen saturation of arterial blood, physical, and mental summary of short form 36.
In conclusion, IMT improves functional outcomes in ICUAWS patients with walking disability.
The clinical trial ID of this ICUAWS trial is NCT06210763.
重症监护病房获得性肌无力综合征（ICUAWS）会给患者的功能活动带来多种并发症，如严重的行走障碍。
我们的目的是评估1个月吸气肌训练（IMT）对患有ICUAWS和严重行走障碍的老年人功能结局的影响。设计、设置、参与者和干预措施。本研究是一项随机对照试验。在改良功能性步行分类测试（MFACT）中抱怨有严重行走障碍的ICUAWS患者被随机分为IMT组或对照组，每组n = 20。两组均接受传统物理治疗方案。
结果显示，ICUAWS患者/组参数的治疗后组间比较表明，IMT组在6分钟步行试验、吸气和呼气肌力量、用力肺活量、起立行走试验、10米步行试验、第1秒用力呼气量、30秒坐立试验、动脉血氧和二氧化碳分压、MFACT、动脉血氧饱和度、简短健康调查问卷36的身体和精神总结方面有显著改善。
总之，IMT可改善患有行走障碍的ICUAWS患者的功能结局。
该ICUAWS试验的临床试验识别号为NCT06210763。
