Kaiser Max, Wang Yuejuan, Ten Oever Sanne, Duecker Felix, Sack Alexander T, van de Ven Vincent
Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, PO Box 616, 6200MD, The Netherlands.
Commun Psychol. 2025 Feb 3;3(1):19. doi: 10.1038/s44271-025-00202-z.
Non-invasive indirect hippocampal-targeted stimulation is of broad scientific and clinical interest. Transcranial alternating current stimulation (tACS) is appealing because it allows oscillatory stimulation to study hippocampal theta (3-8 Hz) activity. We found that tACS administered during functional magnetic resonance imaging yielded a frequency-, mental state- and topologically-specific effect of theta stimulation (but not other frequencies) enhancing right (but not left) hippocampal-cortical connectivity during resting blocks but not during task blocks. Control analyses showed that this effect was not due to possible stimulation-induced changes in signal quality or head movement. Our findings are promising for targeted network modulations of deep brain structures for research and clinical intervention.
非侵入性间接海马靶向刺激具有广泛的科学和临床意义。经颅交流电刺激（tACS）很有吸引力，因为它允许进行振荡刺激以研究海马θ波（3-8赫兹）活动。我们发现，在功能磁共振成像期间给予tACS会产生θ波刺激（而非其他频率）的频率、精神状态和拓扑特异性效应，在静息时段增强右侧（而非左侧）海马-皮质连接性，而在任务时段则不然。对照分析表明，这种效应并非由刺激可能引起的信号质量变化或头部运动所致。我们的研究结果对于深部脑结构的靶向网络调制用于研究和临床干预很有前景。
