Araujo Jhajaira M, Ramon-Cotrina Maria, Quispe-Martinez Rosa, Rios-Rios Mayra, Quispe-Gonzaga Maribel, Saldaña-Reyes Carlos O, Medina Paula, Cornejo Melanie, Pinto Joseph A, Dyer Richard
Centro de Investigación Básica y Traslacional, Lima, Peru.
Escuela Profesional de Medicina Humana, Universidad Privada San Juan Bautista, Lima, Peru.
Cancer Control. 2025 Jan-Dec;32:10732748251318386. doi: 10.1177/10732748251318386.
Human papillomavirus (HPV) infection is a common sexually transmitted infection often associated with cancer development. This study aimed to estimate the prevalence of HPV in women receiving care at the AUNA healthcare network in Peru.
We conducted an observational, descriptive, cross-sectional, retrospective study. A de-identified database of HPV-positive women who underwent the BD Onclarity™ HPV Assay between December 2018 and December 2021 at Auna clinics was analyzed. The database contained information regarding age, city, and HPV type. High-risk HPV types were analyzed individually (16, 18, 31, 45, 51, 52) and pooled [P1 (33, 58), P2 (56,59,66), and P3 (35,39,68)]. The study was approved by an independent research ethics committee in Peru.
Of 68,714 women included in the study, the HPV prevalence was 14.21% (N = 9765, 95%CI:13.95%-14.47%). The highest prevalence was detected in Piura (16.85%, 95%CI:15.40%-18.38%), where HPV-51, HPV-52, HPV-P1, HPV-P2, and HPV-P3 were most common compared to other Peruvian cities included in the study. In Arequipa, the prevalence was the lowest (13.58%, 95%CI:12.38%-14.85%), but the percentage prevalence of HPV-16 was the highest compared to other cities. The prevalence of multiple HPV infections was 2.88% (N = 1981, 95%CI:2.76%-3.01%), with most of them co-presenting two types of HPV (N = 1522). The most frequent co-occurrences were P2 and P3, P2 and 52, and P2 and 16. Among HPV-positive women, the mean age was 41.31 years (±9.48) and 25.29% were in the 31-35 years group. HPV-P2 was the most frequent in all age groups except in the 65-72 years group, where HPV-P3 was the most common.
HPV prevalence was shown to be highest in Piura, with the most prevalent types being HPV-16, HPV-52, and HPV-P2 (HPV-56, -59, -66). HPV infection was found to be more frequent among women in the 31-35 years age group.
人乳头瘤病毒（HPV）感染是一种常见的性传播感染，常与癌症发展相关。本研究旨在估计在秘鲁奥纳医疗网络接受护理的女性中HPV的流行率。
我们进行了一项观察性、描述性、横断面、回顾性研究。分析了2018年12月至2021年12月期间在奥纳诊所接受BD Onclarity™ HPV检测的HPV阳性女性的去识别数据库。该数据库包含年龄、城市和HPV类型等信息。对高危HPV类型进行了单独分析（16、18、31、45、51、52）和合并分析[P1（33、58）、P2（56、59、66）和P3（35、39、68）]。该研究获得了秘鲁独立研究伦理委员会的批准。
在纳入研究的68714名女性中，HPV流行率为14.21%（N = 9765，95%CI：13.95%-14.47%）。皮斯科的流行率最高（16.85%，95%CI：15.40%-18.38%），与研究中纳入的其他秘鲁城市相比，HPV-51、HPV-52、HPV-P1、HPV-P2和HPV-P3在那里最为常见。在阿雷基帕，流行率最低（13.58%，95%CI：12.38%-14.85%），但与其他城市相比，HPV-16的流行率百分比最高。多重HPV感染的流行率为2.88%（N = 1981，95%CI：2.76%-3.01%），其中大多数同时感染两种类型的HPV（N = 1522）。最常见的同时感染组合是P2和P3、P2和52以及P2和16。在HPV阳性女性中，平均年龄为41.31岁（±9.48），25.29%在31-35岁年龄组。除65-72岁年龄组中HPV-P3最常见外，HPV-P2在所有年龄组中最常见。
皮斯科的HPV流行率最高，最常见的类型是HPV-16、HPV-52和HPV-P2（HPV-56、-59、-66）。发现HPV感染在31-35岁年龄组的女性中更为频繁。
