伴有口腔受累的坏疽性脓皮病及多学科管理
Pyoderma Gangrenosum with Oral Involvement and Multidisciplinary Management.
作者信息
de Souza Camargo Héric, da Silva Nunes Carolina, Navarro Claudia Maria, Massucato Elaine Maria Sgavioli, Gabrielli Marisa Aparecida Cabrini, Filho Valfrido Antonio Pereira, Bufalino Andreia
机构信息
Department of Diagnosis and Surgery, School of Dentistry, São Paulo State University (Unesp), Rua Humaitá, 1980, Centro, Araraquara, São Paulo CEP 14801-903 Brazil.
出版信息
J Maxillofac Oral Surg. 2025 Feb;24(1):59-61. doi: 10.1007/s12663-024-02218-0. Epub 2024 Jun 11.
INTRODUCTION
Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis often associated with inflammatory bowel disease.
CASE REPORT
We present a case of PG affecting the oral mucosa in a 31-year-old female with ulcerative colitis, necessitating total colectomy due to aggressive lesion progression. Despite initial adalimumab treatment, the lesions persisted, prompting a multidisciplinary approach. Following surgical intervention, including total colectomy and microvascularized graft with a forearm flap, the patient remained recurrence-free during a seven-year follow-up.
CONCLUSION
This case underscores the complexity of PG and highlights the efficacy of a comprehensive therapeutic approach, emphasizing the importance of individualized management strategies in severe cases.
引言
坏疽性脓皮病（PG）是一种罕见的嗜中性皮病，常与炎症性肠病相关。
病例报告
我们报告一例31岁患有溃疡性结肠炎的女性发生口腔黏膜PG的病例，由于病变进展迅速，需要进行全结肠切除术。尽管最初使用阿达木单抗治疗，但病变仍持续存在，促使采取多学科方法。在包括全结肠切除术和前臂皮瓣微血管化移植在内的手术干预后，患者在七年随访期间未复发。
结论
该病例强调了PG的复杂性，并突出了综合治疗方法的有效性，强调了在严重病例中个体化管理策略的重要性。
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