Wang Xiaolei, Zheng Meifeng, Qin Shuangmei, Li Yimei, Xu Huifang
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University.
Ginekol Pol. 2025;96(3):184-191. doi: 10.5603/gpl.102215. Epub 2025 Feb 4.
This study aimed to identify the effects of acute aerobic exercise combined with resistance exercise on maternal glucose metabolism and sympathetic nervous system-regulated cardiovascular function in overweight or obese pregnancies.
We conducted a randomized controlled trial of aerobic exercise combined with resistance training (aerobic + resistance; n = 25) compared with aerobic exercise (aerobic, n = 21) beginning at 16 wk and continuing until 36 wk of gestation in overweight or obese pregnant women. At preintervention and postintervention assessments, the glycometabolism, muscle sympathetic nervous system activity (MSNA) and cardiovascular parameters were measured and analyzed, containing fasting blood glucose (FBG), fasting blood insulin (FBI), 2 h glucose, glycosylated hemoglobin (HbA1c), homeostatic model assessment of insulin resistance (HOMA-IR), MSNA bursts/min, MSNA bursts/100 heartbeats, resting heart rate (HR); diastolic blood pressure (DBP), mean arterial pressure (MAP), systolic blood pressure (SBP), cardiac index (CI), cardiac output (CO), stroke volume (SV), total peripheral resistance (TPR) and total peripheral resistance index (TPRI).
Compared to aerobic group, the overweight or obese pregnant women in aerobic + resistance group showed lower FBG, FBI, 2 h glucose, HbA1c and HOMA-IR (p < 0.05). Moreover, both MSNA bursts/min and MSNA burst/100 heartbeats level were reduced in aerobic + resistance group compared to aerobic group (p < 0.0001). Finally, the resting HR, DBP, SBP, MAP, CI, CO and TPRI were significantly decreased in aerobic + resistance group compared to aerobic group (p < 0.05).
In summary, aerobic exercise combined with resistance training was associated with improved glycometabolism, MSNA and cardiovascular function in overweight or obese pregnant women compared to aerobic exercise alone.
本研究旨在确定急性有氧运动与抗阻运动相结合对超重或肥胖孕妇的母体葡萄糖代谢及交感神经系统调节的心血管功能的影响。
我们进行了一项随机对照试验，将超重或肥胖孕妇从妊娠16周开始至36周进行有氧运动与抗阻训练相结合（有氧+抗阻；n = 25）与有氧运动（有氧组，n = 21）相比较。在干预前和干预后评估中，测量并分析糖代谢、肌肉交感神经系统活动（MSNA）和心血管参数，包括空腹血糖（FBG）、空腹血胰岛素（FBI）、2小时血糖、糖化血红蛋白（HbA1c）、胰岛素抵抗稳态模型评估（HOMA-IR）、MSNA爆发次数/分钟、MSNA爆发次数/100次心跳、静息心率（HR）；舒张压（DBP）、平均动脉压（MAP）、收缩压（SBP）、心脏指数（CI）、心输出量（CO）、每搏输出量（SV）、总外周阻力（TPR）和总外周阻力指数（TPRI）。
与有氧运动组相比，有氧+抗阻组的超重或肥胖孕妇的FBG,FBI,2小时血糖、HbA1c和HOMA-IR较低（p < 0.05）。此外，与有氧运动组相比，有氧+抗阻组的MSNA爆发次数/分钟和MSNA爆发次数/100次心跳水平均降低（p < 0.0001）。最后，与有氧运动组相比，有氧+抗阻组的静息HR、DBP、SBP、MAP、CI、CO和TPRI显著降低（p < 0.05）。
总之，与单独进行有氧运动相比，有氧运动与抗阻训练相结合可改善超重或肥胖孕妇的糖代谢、MSNA和心血管功能。
