皮质酮外周转化为皮质醇过程中的一种新缺陷。
A new defect in the peripheral conversion of cortisone to cortisol.
作者信息
Phillipou G, Higgins B A
出版信息
J Steroid Biochem. 1985 Mar;22(3):435-6. doi: 10.1016/0022-4731(85)90451-0.
PMID:3990293
Abstract
A steroid disorder is described in two sisters, aged 13 and 17 years, in which the metabolism of cortisol results almost exclusively in urinary excretion of tetrahydro-cortisone (11-keto) derivatives. The evidence implies the existence of a deficiency in the peripheral enzymatic conversion of cortisone to cortisol.
摘要
在两名分别为13岁和17岁的姐妹中描述了一种类固醇疾病，其中皮质醇的代谢几乎完全导致四氢可的松（11-酮）衍生物经尿液排泄。证据表明存在可的松在外周酶促转化为皮质醇的缺陷。
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