Nishimura Michiko, Hoshino Miyako, Miyazaki Yuji, Sakamoto Shinnichi, Ide Fumio, Nomura Tsutomu, Kusama Kaoru, Kikuchi Kentaro
Division of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama, 350-0283, Japan.
Division of Basic Biology, Department of Oral Biology and Tissue Engineering, Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama, 350-0283, Japan.
Med Mol Morphol. 2025 Feb 4. doi: 10.1007/s00795-025-00420-8.
Oncocytic sinonasal papilloma (OSP) is an uncommon, benign neoplasm characterized by papillary growths arising from the Schneiderian mucosa of the nasal and paranasal sinuses. OSP accounts for about 3-6% of all sinonasal papillomas (SPs), and clinically is often confused with inverted sinonasal papilloma (incidence 73%). Although SP shares some of the clinical characteristics of OSP, the pathogenesis differs and it is very important to distinguish between them. Here we present a case of OSP in the nasal and paranasal sinuses of a 67-year-old Japanese male, who complained of persistent left-sided nasal obstruction. A benign nasal paranasal tumor was diagnosed, and endoscopic sinus surgery was performed. Histopathologically, the tumor cells exhibited an exophytic and endophytic growth pattern, composed of multilayered eosinophilic columnar epithelium with finely granular cytoplasm, and forming microcysts filled with mucin or microabscesses. The epithelium was PTAH-positive, and showed positivity for cytokeratin-7 with oncocytic features. A review of the literature revealed 166 cases of OSP in the nasal and paranasal sinuses, with an overall recurrence rate of about 15%. Here we report a case of OSP in the nasal and paranasal sinuses for which PTAH staining specific for oncocytes was useful, together with a review of the relevant literature.
嗜酸细胞性鼻鼻窦乳头状瘤（OSP）是一种罕见的良性肿瘤，其特征为起源于鼻和鼻窦施耐德氏黏膜的乳头状生长。OSP约占所有鼻鼻窦乳头状瘤（SPs）的3%-6%，临床上常与内翻性鼻鼻窦乳头状瘤（发病率73%）相混淆。尽管SP与OSP有一些共同的临床特征，但其发病机制不同，区分两者非常重要。在此，我们报告一例67岁日本男性鼻和鼻窦的OSP病例，该患者主诉持续性左侧鼻塞。诊断为良性鼻旁窦肿瘤，并进行了鼻内镜鼻窦手术。组织病理学检查显示，肿瘤细胞呈外生性和内生性生长模式，由多层嗜酸性柱状上皮组成，细胞质呈细颗粒状，并形成充满黏液的微囊肿或微脓肿。上皮PTAH染色阳性，细胞角蛋白-7呈阳性，具有嗜酸细胞特征。文献复习显示，鼻和鼻窦OSP病例有166例，总复发率约为15%。在此，我们报告一例鼻和鼻窦OSP病例，其中对嗜酸细胞特异的PTAH染色很有用，并对相关文献进行了复习。
