Greer Daniel, Atherton Jennifer, Girgis Justina
Ernest Mario School of Pharmacy Rutgers University Piscataway New Jersey USA.
St. Joseph's University Medical Center Paterson New Jersey USA.
PCN Rep. 2025 Feb 4;4(1):e70060. doi: 10.1002/pcn5.70060. eCollection 2025 Mar.
Delta-9-tetrahydrocannabiphorol (Δ-THCP) is a potent phytocannabinoid found naturally in the cannabis plant in small quantities. This cannabinoid is noted to potently bind to cannabinoid receptor 1 and cannabinoid receptor 2 and is reported to be highly psychoactive. A small amount of Δ-THCP is found naturally, which led to its isolation and synthetic production. This isolate is beginning to be sold at dispensaries. Information on Δ-THCP is sparse and case reports of adverse events add to the current literature.
This case report describes a patient who was brought into the emergency department with a self-inflicted stab wound to the chest after consuming 8 mg of Δ-THCP. The patient was a regular user of standard tetrahydrocannabinol (THC) products from dispensaries and had no history of psychotic symptoms. The patient consumed the 8 mg just over 2 days prior to admission and noted psychotic symptoms for 48 h. The symptoms included depersonalization and a belief that he was already dead. A single dose of haloperidol 5 mg intravenous push was administered in the intensive care unit due to agitation. Afterwards, the patient refused all oral antipsychotics and the psychotic symptoms cleared prior to discharge.
The case adds to the evidence suggesting that Δ-THCP is highly potent and psychoactive. Even experienced users of THC may have adverse effects to Δ-THCP due to differences in binding and potency. Isolates of phytocannabinoids require caution prior to use.
Δ-9-四氢大麻酚（Δ-THCP）是一种在大麻植物中天然存在的少量强效植物大麻素。这种大麻素被认为能与大麻素受体1和大麻素受体2强力结合，据报道具有高度精神活性。由于天然存在的Δ-THCP量很少，因此对其进行了分离和合成生产。这种分离物开始在药房销售。关于Δ-THCP的信息很少，不良事件的病例报告增加了当前的文献资料。
本病例报告描述了一名患者，其在服用8毫克Δ-THCP后自伤胸部，被送往急诊科。该患者是药房标准四氢大麻酚（THC）产品的常规使用者，无精神症状病史。患者在入院前2天多服用了8毫克Δ-THCP，并在48小时内出现精神症状。症状包括人格解体和认为自己已经死亡的信念。由于患者躁动不安，在重症监护病房静脉推注了一剂5毫克的氟哌啶醇。之后，患者拒绝了所有口服抗精神病药物，精神症状在出院前消失。
该病例进一步证明了Δ-THCP具有高效力和精神活性。由于结合和效力的差异，即使是经验丰富的THC使用者也可能对Δ-THCP产生不良反应。在使用植物大麻素分离物之前需要谨慎。
