Liu Heqian, Wu Yifei, Liu Zhenyu, Ren Hongzhi, Wu Ya, Liu Yong
Department of Vascular Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Metabolic Vascular Disease Key Laboratory of Sichuan Province, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Front Nutr. 2025 Jan 20;12:1469449. doi: 10.3389/fnut.2025.1469449. eCollection 2025.
Abdominal aortic calcification (AAC) is prevalent among middle-aged and elderly populations, elevating the risk of cardiovascular and cerebrovascular events. Leveraging data from the National Health and Nutrition Examination Survey (NHANES), we conducted a nationally representative cross-sectional study. Our aim was to evaluate whether subjective interventions could influence AAC scores by modifying the antioxidant/pro-oxidant status of individuals and to investigate the role of glycohemoglobin in this relationship.
The study analyzed data from 1,600 U.S. adults. The study used oxidation balance score (OBS) as an exposure variable derived from 16 dietary and 4 lifestyle factors, as well as glycohemoglobin obtained from blood tests. The main outcome measure was AAC, which was evaluated by dual-energy X-ray absorption and quantified by Kauppila scoring system.
The mean (SD) age of the 1,600 patients was 56.53 (10.90) years, with a female predominance (50.22%). According to weighted linear regressions not adjusted for covariates, the AAC scores were lower in the third and fourth quartile groups of OBS than in the first quartile group of OBS (Q3: coefficients [coef], -0.92 [95% CI, -1.64 to-0.20], = 0.017; Q4: coefficients [coef], -0.97 [95% CI, -1.86 ~ -0.08; < 0.035]). According to the weighted linear regression subgroup analyses, there were no significant OBS-AAC correlations among males ( > 0.05), but there were significant correlations among females ( < 0.05). Smooth fitting curves showed a more significant trend of change in the negative correlation between OBS and AAC scores in postmenopausal women than in premenopausal women. In further mediation analyses, glycohemoglobin was identified as a mediator of the relationship between the oxidative balance score and AAC.
This study revealed a significant negative correlation between OBS and AAC scores, particularly in postmenopausal women. The negative correlation between OBS and AAC is partly mediated by glycohemoglobin.
腹主动脉钙化（AAC）在中老年人群中普遍存在，会增加心血管和脑血管事件的风险。利用美国国家健康与营养检查调查（NHANES）的数据，我们开展了一项具有全国代表性的横断面研究。我们的目的是评估主观干预措施是否可以通过改变个体的抗氧化/促氧化状态来影响AAC评分，并研究糖化血红蛋白在这种关系中的作用。
该研究分析了1600名美国成年人的数据。该研究将氧化平衡评分（OBS）用作一个暴露变量，该变量源自16种饮食和4种生活方式因素，同时还使用了血液检测获得的糖化血红蛋白。主要结局指标是AAC，通过双能X线吸收法进行评估，并采用考皮拉评分系统进行量化。
1600名患者的平均（标准差）年龄为56.53（10.90）岁，女性占多数（50.22%）。根据未针对协变量进行调整的加权线性回归分析，OBS的第三和第四四分位数组的AAC评分低于OBS的第一四分位数组（Q3：系数[coef]，-0.92[95%CI，-1.64至-0.20]，P=0.017；Q4：系数[coef]，-0.97[95%CI，-1.86至-0.08]；P<0.035）。根据加权线性回归亚组分析，男性中OBS与AAC之间无显著相关性（P>0.05），但女性中存在显著相关性（P<0.05）。平滑拟合曲线显示，绝经后女性中OBS与AAC评分之间的负相关变化趋势比绝经前女性更显著。在进一步的中介分析中，糖化血红蛋白被确定为氧化平衡评分与AAC之间关系的中介因素。
本研究揭示了OBS与AAC评分之间存在显著的负相关，尤其是在绝经后女性中。OBS与AAC之间的负相关部分由糖化血红蛋白介导。
