Department of Orthopedic Surgery, The Spine Surgical Center, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, China.
Department of Laboratory Medicine, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, China.
J Nanobiotechnology. 2024 Feb 28;22(1):80. doi: 10.1186/s12951-024-02337-3.
The advancement of biomaterials with antimicrobial and wound healing properties continues to present challenges. Macrophages are recognized for their significant role in the repair of infection-related wounds. However, the interaction between biomaterials and macrophages remains complex and requires further investigation. In this research, we propose a new sequential immunomodulation method to enhance and expedite wound healing by leveraging the immune properties of bacteria-related wounds, utilizing a novel mixed hydrogel dressing. The hydrogel matrix is derived from porcine acellular dermal matrix (PADM) and is loaded with a new type of bioactive glass nanoparticles (MBG) doped with magnesium (Mg-MBG) and loaded with Curcumin (Cur). This hybrid hydrogel demonstrates controlled release of Cur, effectively eradicating bacterial infection in the early stage of wound infection, and the subsequent release of Mg ions (Mg) synergistically inhibits the activation of inflammation-related pathways (such as MAPK pathway, NF-κB pathway, TNF-α pathway, etc.), suppressing the inflammatory response caused by infection. Therefore, this innovative hydrogel can safely and effectively expedite wound healing during infection. Our design strategy explores novel immunomodulatory biomaterials, offering a fresh approach to tackle current clinical challenges associated with wound infection treatment.
具有抗菌和伤口愈合性能的生物材料的不断发展仍然存在挑战。巨噬细胞因其在感染相关伤口修复中的重要作用而得到认可。然而，生物材料与巨噬细胞之间的相互作用仍然很复杂，需要进一步研究。在这项研究中，我们提出了一种新的序贯免疫调节方法，利用与细菌相关的伤口的免疫特性，利用新型混合水凝胶敷料来增强和加速伤口愈合。水凝胶基质来源于猪去细胞真皮基质（PADM），并负载一种新型载镁的生物活性玻璃纳米粒子（MBG）（Mg-MBG）和姜黄素（Cur）。这种杂化水凝胶表现出姜黄素的控制释放，在伤口感染的早期有效消除细菌感染，随后释放的镁离子（Mg）协同抑制炎症相关途径的激活（如 MAPK 途径、NF-κB 途径、TNF-α 途径等），抑制感染引起的炎症反应。因此，这种创新的水凝胶可以在感染期间安全有效地加速伤口愈合。我们的设计策略探索了新型免疫调节生物材料，为解决当前与伤口感染治疗相关的临床挑战提供了新的方法。
