Kromhout D, Feskens E J, Bowles C H
Division of Public Health Research, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.
Int J Epidemiol. 1995 Apr;24(2):340-5. doi: 10.1093/ije/24.2.340.
A protective effect of a small amount of fish on coronary heart disease (CHD) mortality has been established in observational studies in middle-aged people. In the present study this association was investigated in the elderly.
In 1971 CHD risk factors were measured in 272 people born before 1907. They belonged to a general practice in Rotterdam, the Netherlands and were followed for 17 years. The cross-check dietary history method was used to obtain information on fish consumption.
During the follow-up period 58 people died from CHD, 67 from cancer and 187 from all causes. In 1971 about 60% of the elderly ate fish and 40% did not eat fish. Multivariate Cox proportional hazards analyses, taking the confounding effect of major risk factors into account, showed an inverse relation between fish consumption and 17-year CHD mortality. The risk ratio (RR) for fish eaters compared with no-fish eaters was significantly different from unity (RR = 0.51, 95% CI: 0.29-0.89). Cancer and total mortality were not related to fish consumption.
The results from the present study suggest that the protective effect of a small amount of fish in relation to CHD observed in middle-aged people seems also to be present in the elderly.
在针对中年人的观察性研究中，已证实少量食用鱼类对冠心病（CHD）死亡率具有保护作用。在本研究中，对老年人中的这种关联进行了调查。
1971年，对272名1907年以前出生的人进行了冠心病危险因素测量。他们来自荷兰鹿特丹的一家普通诊所，并接受了17年的随访。采用交叉核对饮食史方法获取鱼类消费信息。
在随访期间，58人死于冠心病，67人死于癌症，187人死于各种原因。1971年，约60%的老年人食用鱼类，40%不食用鱼类。在考虑主要危险因素的混杂效应后进行的多变量Cox比例风险分析显示，鱼类消费与17年冠心病死亡率之间呈负相关。食用鱼类者与不食用鱼类者的风险比（RR）显著不同于1（RR = 0.51，95%可信区间：0.29 - 0.89）。癌症和总死亡率与鱼类消费无关。
本研究结果表明，在中年人中观察到的少量食用鱼类对冠心病的保护作用在老年人中似乎也存在。
