Shi Shuo, Jiang Wenbao, Zhao Tianxiao, Aifantis Katerina E, Wang Hui, Lin Lei, Fan Yubo, Feng Qingling, Cui Fu-zhai, Li Xiaoming
Department of Orthopedics, The First Hospital of Hebei Medical University, Shijiazhuang, 050031, China.
Department of General Surgery, Zhangbei Hospital, Zhangbei, 076450, China.
J Biomed Mater Res A. 2015 Dec;103(12):3978-92. doi: 10.1002/jbm.a.35522. Epub 2015 Jun 29.
Bone regeneration is a complicated process that involves a series of biological events, such as cellular recruitment, proliferation and differentiation, and so forth, which have been found to be significantly affected by controlled drug delivery. Recently, a lot of research studies have been launched on the application of nanomaterials in controlled drug delivery for bone regeneration. In this article, the latest research progress in this area regarding the use of bioceramics-based, polymer-based, metallic oxide-based and other types of nanomaterials in controlled drug delivery for bone regeneration are reviewed and discussed, which indicates that the controlling drug delivery with nanomaterials should be a very promising treatment in orthopedics. Furthermore, some new challenges about the future research on the application of nanomaterials in controlled drug delivery for bone regeneration are described in the conclusion and perspectives part.
骨再生是一个复杂的过程，涉及一系列生物学事件，如细胞募集、增殖和分化等，已发现这些过程会受到控释给药的显著影响。最近，针对纳米材料在骨再生控释给药中的应用开展了大量研究。本文综述并讨论了该领域在基于生物陶瓷、聚合物、金属氧化物及其他类型纳米材料用于骨再生控释给药方面的最新研究进展，这表明利用纳米材料进行控释给药在骨科领域应是一种非常有前景的治疗方法。此外，在结论与展望部分描述了纳米材料在骨再生控释给药应用未来研究的一些新挑战。
