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在有或没有侧向流动脂阿拉伯甘露聚糖检测的情况下，对呼吸道样本和粪便同时使用低复杂度自动核酸扩增检测来检测儿童肺结核病。

Parallel use of low-complexity automated nucleic acid amplification tests on respiratory samples and stool with or without lateral flow lipoarabinomannan assays to detect pulmonary tuberculosis disease in children.

作者信息

Olbrich Laura, Kay Alexander W, Bjerrum Stephanie, Yang Bada, Åhsberg Johanna, Nathavitharana Ruvandhi R, Lundh Andreas, Shah Maunank, Jaganath Devan

机构信息

Division of Infectious Diseases and Tropical Medicine, LMU University Hospital Munich, Munich, Germany.

Partner Site Munich, German Centre for Infection Research (DZIF), Munich, Germany.

出版信息

Cochrane Database Syst Rev. 2024 May 13;5(5):CD016071. doi: 10.1002/14651858.CD016071.

DOI:10.1002/14651858.CD016071
PMID:39908066
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11089514/
Abstract

This is a protocol for a Cochrane Review (diagnostic). The objectives are as follows: To compare the diagnostic accuracy of the parallel use of low-complexity automated nucleic acid amplification tests on respiratory and stool specimens in children and lateral flow urine lipoarabinomannan amongst children with HIV versus each assay alone for detecting pulmonary tuberculosis. Secondary objectives To compare the diagnostic accuracy of low-complexity automated nucleic acid amplification tests on respiratory and stool specimens in combination versus each sample type alone. To investigate the following sources of heterogeneity: clinical setting, signs and symptoms of pulmonary tuberculosis disease, screening positivity by chest X-ray abnormalities, age group, specimen type; and also amongst children with HIV: CD4 cell-count or percent category, advanced HIV disease, and serious illness.

摘要

这是一项Cochrane系统评价（诊断性）的方案。目标如下：比较在儿童中同时使用低复杂度自动化核酸扩增检测法检测呼吸道和粪便标本以及使用侧流尿脂阿拉伯甘露聚糖检测法与单独使用每种检测方法检测HIV感染儿童肺结核的诊断准确性。次要目标：比较联合使用低复杂度自动化核酸扩增检测法检测呼吸道和粪便标本与单独检测每种样本类型的诊断准确性。调查以下异质性来源：临床环境、肺结核疾病的体征和症状、胸部X线异常筛查阳性率、年龄组、标本类型；以及在HIV感染儿童中：CD4细胞计数或分类百分比、晚期HIV疾病和重症。

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Parallel use of low-complexity automated nucleic acid amplification tests on respiratory samples and stool with or without lateral flow lipoarabinomannan assays to detect pulmonary tuberculosis disease in children.在有或没有侧向流动脂阿拉伯甘露聚糖检测的情况下，对呼吸道样本和粪便同时使用低复杂度自动核酸扩增检测来检测儿童肺结核病。
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引用本文的文献

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Parallel use of low-complexity automated nucleic acid amplification tests on respiratory and stool samples with or without lateral flow lipoarabinomannan assays to detect pulmonary tuberculosis disease in children.在有或没有侧向流动脂阿拉伯甘露聚糖检测的情况下，对呼吸道和粪便样本并行使用低复杂度自动核酸扩增检测以检测儿童肺结核病。
Cochrane Database Syst Rev. 2025 Jun 11;6(6):CD016071. doi: 10.1002/14651858.CD016071.pub2.
2
Parallel use of low-complexity automated nucleic acid amplification tests and lateral flow urine lipoarabinomannan assays to detect tuberculosis disease in adults and adolescents living with HIV.并行使用低复杂度自动化核酸扩增检测和侧向流动尿液脂阿拉伯甘露聚糖检测，以检测感染艾滋病毒的成人和青少年中的结核病。
Cochrane Database Syst Rev. 2025 Jun 10;6(6):CD016070. doi: 10.1002/14651858.CD016070.pub2.

本文引用的文献

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Diagnostic yield of urine lipoarabinomannan and sputum tuberculosis tests in people living with HIV: a systematic review and meta-analysis of individual participant data.对 HIV 感染者进行尿液脂阿拉伯甘露聚糖检测和痰结核分枝杆菌检测的诊断效果：一项个体参与者数据的系统评价和荟萃分析。
Lancet Glob Health. 2023 Jun;11(6):e903-e916. doi: 10.1016/S2214-109X(23)00135-3.
2
Expedited diagnosis of pediatric tuberculosis using Truenat MTB-Rif Dx and GeneXpert MTB/RIF.使用 Truenat MTB-Rif Dx 和 GeneXpert MTB/RIF 快速诊断儿童结核病。
Sci Rep. 2023 Apr 28;13(1):6976. doi: 10.1038/s41598-023-32810-2.
3
Xpert MTB/RIF Ultra assay for tuberculosis disease and rifampicin resistance in children.Xpert MTB/RIF Ultra assay 用于儿童结核病和利福平耐药检测。
Cochrane Database Syst Rev. 2022 Sep 6;9(9):CD013359. doi: 10.1002/14651858.CD013359.pub3.
4
Value of urine-based lipoarabinomannan (LAM) antigen tests for diagnosing tuberculosis in children: systematic review and meta-analysis.基于尿液的脂阿拉伯甘露聚糖（LAM）抗原检测在儿童结核病诊断中的价值：系统评价与荟萃分析。
IJID Reg. 2022 Jun 23;4:97-104. doi: 10.1016/j.ijregi.2022.06.004. eCollection 2022 Sep.
5
HIV-Associated Tuberculosis in Children and Adolescents: Evolving Epidemiology, Screening, Prevention and Management Strategies.儿童和青少年中的HIV相关结核病：不断演变的流行病学、筛查、预防及管理策略
Pathogens. 2021 Dec 29;11(1):33. doi: 10.3390/pathogens11010033.
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QUADAS-C: A Tool for Assessing Risk of Bias in Comparative Diagnostic Accuracy Studies.QUADAS-C：用于评估诊断准确性比较研究偏倚风险的工具。
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Cochrane Database Syst Rev. 2021 Mar 23;3(3):CD013694. doi: 10.1002/14651858.CD013694.pub2.
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JAMA Pediatr. 2021 May 1;175(5):e206069. doi: 10.1001/jamapediatrics.2020.6069. Epub 2021 May 3.