Osaki Keiichi, Morishita Shinichiro, Nakano Jiro, Inoue Junichiro, Okayama Taro, Suzuki Katsuyoshi, Tanaka Takashi, Fukushima Takuya
Department of Rehabilitation, Panasonic Health Insurance Organization, Matsushita Memorial Hospital.
Department of Physical Therapy, School of Health Sciences, Fukushima Medical University School of Health Science.
Fukushima J Med Sci. 2025 Apr 19;71(2):73-84. doi: 10.5387/fms.24-00042. Epub 2025 Feb 8.
This meta-analysis aimed to investigate the impact of pretreatment quality of life (QoL) on overall survival (OS) in patients with hematological malignancies. The observational studies with relationship between QoL and OS in patients undergoing either hematopoietic stem cell transplantation (HSCT) or chemotherapy were collected. Stratification by treatment was performed to examine the association between QoL and OS. Six articles were included in the analysis. Overall, significant associations with OS were observed for global QoL (hazard ratio [HR] = 1.04, 95% confidence interval [CI] = 1.01-1.08), physical QoL (HR = 1.06, 95% CI:1.02-1.10), and social QoL (HR = 1.02, 95% CI: 1.00-1.03). When stratified by treatment, HSCT showed significant associations between OS and both global QoL (HR = 1.05, 95% CI:1.00-1.11) and physical QoL (HR = 1.03, 95% CI:1.00-1.06). For chemotherapy, significant associations were also observed between OS and global QoL (HR = 1.04, 95% CI:1.00-1.09), physical QoL (HR = 1.08, 95% CI:1.00-1.17), role QoL (HR = 1.02, 95% CI:1.00-1.04), and social QoL (HR = 1.02, 95% CI:1.00-1.04). No significant associations were observed regarding emotional QoL, which was only analyzed in HSCT. The factors influencing OS may vary depending on the treatment, emphasizing the importance of recognizing QoL from the pretreatment stage.
这项荟萃分析旨在研究血液系统恶性肿瘤患者治疗前生活质量（QoL）对总生存期（OS）的影响。收集了关于接受造血干细胞移植（HSCT）或化疗患者的QoL与OS之间关系的观察性研究。按治疗方式进行分层，以检验QoL与OS之间的关联。分析纳入了6篇文章。总体而言，观察到全球生活质量（风险比[HR]=1.04，95%置信区间[CI]=1.01-1.08）、身体生活质量（HR=1.06，95%CI：1.02-1.10）和社会生活质量（HR=1.02，95%CI：1.00-1.03）与OS存在显著关联。按治疗方式分层时，HSCT显示OS与全球生活质量（HR=1.05，95%CI：1.00-1.11）和身体生活质量（HR=1.03，95%CI：1.00-1.06）均存在显著关联。对于化疗，OS与全球生活质量（HR=1.04，95%CI：1.00-1.09）、身体生活质量（HR=1.08，95%CI：1.00-1.17）、角色生活质量（HR=1.02，95%CI：1.00-1.04）和社会生活质量（HR=1.02，95%CI：1.00-1.04）之间也观察到显著关联。在仅针对HSCT分析的情感生活质量方面，未观察到显著关联。影响OS的因素可能因治疗方式而异，这凸显了从治疗前阶段就认识到生活质量的重要性。
